Effect of short-chain fatty acids on cyclic 3′,5′-guanosine monophosphate-mediated colonic secretion

被引:16
作者
Charney, AN
Giannella, RA
Egnor, RW
机构
[1] NYU, Sch Med, Nephrol Sect, VA Med Ctr, New York, NY 10010 USA
[2] Univ Cincinnati, Coll Med, Div Digest Dis, VA Med Ctr, Cincinnati, OH 45267 USA
来源
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY | 1999年 / 124卷 / 02期
关键词
Sprague-Dawley rats; pH(i); ion flux; E-coli heat-stable enterotoxin (STa);
D O I
10.1016/S1095-6433(99)00107-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Short chain fatty acids (SCFA) prevent and reverse cyclic 3',5'-adenosine monophosphate (cAMP) but not Ca2+-mediated Cl- secretion. Mucosal [HCO3-](i) has an opposite effect on these secretagogues. We examined whether SCFA and [HCO3-](i) affect cyclic 3',5'-guanosine monophosphate (cGMP)-induced secretion. Stripped segments of male Sprague-Dawley rat (Rattus norvegicus) proximal and distal colon, and cultured T84 cells were studied in Ussing chambers, and pH(i) and [HCO3-](i) were determined. Mucosal [cGMP] was measured in proximal colon. In T84 cells, the increase in Cl- secretion (measured as I-sc) induced by mucosal 0.25 mu M Escherichia coli heat-stable enterotoxin (STa) was prevented/reversed by bilateral 50 mM Na+ butyrate (71%/73%), acetate (58%/76%), propionate (68%/73%) and (poorly metabolized) isobutyrate (80%/79%). In proximal colon in HCO, Ringer, basal Cl- secretion was not affected by [HCO3-](i) 25 mM butyrate. Mucosal 0.25 mu M STa decreased net Na+ and Cl- absorption. Bilateral but not mucosal 25 mM SCFA reversed STa-induced effects on Na+ absorption and Cl- secretion. Bilateral and mucosal 25 mM SCFA but not [HCO3-](i) prevented STa-induced Cl- secretion and increases in mucosal [cGMP]. STa did not produce Cl- secretion in distal colon. It was concluded that SCFA but not [HCO3-](i) can prevent and reverse cGMP-induced colonic Cl- secretion. (C) 1999 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:169 / 178
页数:10
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