Total synthesis of cyclostellettamine C, a bispyridinium macrocyclic alkaloid having muscarinic acetylcholine receptor antagonistic activity

被引：28

作者：

Anan, H ^{[1
]}

Seki, N ^{[1
]}

Noshiro, O ^{[1
]}

Honda, K ^{[1
]}

Yasumuro, K ^{[1
]}

Ozasa, T ^{[1
]}

Fusetani, N ^{[1
]}

机构：

[1] UNIV TOKYO,GRAD SCH AGR LIFE SCI,LAB AQUAT NAT PROD CHEM,BUNKYO KU,TOKYO 113,JAPAN

来源：

TETRAHEDRON | 1996年 / 52卷 / 33期

关键词：

D O I：

10.1016/0040-4020(96)00628-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cyclostellettamine C (1), a bispyridinium macrocyclic compound having muscarinic acetylcholine receptor antagonistic activity, was synthesized by the stepwise ring closure method via 3-(13-hydroxytridecyl)-1-[13-(3-pyridyl)tridecyl]pyridinium trifluoromethanesulfonate (21). Through this study, the structure of naturally originating 1 was synthetically and biologically confirmed. Copyright (C) 1996 Published by Elsevier Science Ltd

引用

页码：10849 / 10860

页数：12

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