Transmission of Salmonella enterica, serotype Typhimurium in poultry with and without antimicrobial selective pressure

被引:14
作者
Bauer-Garland, J.
Frye, J. G.
Gray, J. T.
Berrang, M. E.
Harrison, M. A.
Fedorka-Cray, P. J.
机构
[1] USDA ARS, Bacterial Epidemiol & Antimicrobial Resistance Re, Richard B Russell Agr Res Ctr, Athens, GA 30605 USA
[2] Univ Guelph, Dept Pathobiol, Guelph, ON N1G 2W1, Canada
[3] Univ Georgia, Dept Food Sci & Technol, Athens, GA 30602 USA
关键词
antimicrobial resistance; antimicrobial selective pressure; poultry; Salmonella Typhimurium; tetracycline; transmission;
D O I
10.1111/j.1365-2672.2006.03036.x
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Aims: To determine the effect of antimicrobial selective pressure on the transmission of antimicrobial resistant and sensitive strains of Salmonella in poultry. Methods and Results: Eight pens housed 12 broiler chicks each. Two chicks in four of the pens were inoculated with a Salm. Typhimurium strain resistant to 12 antimicrobials (including tetracycline), and two chicks in each of the four other pens were inoculated with a strain sensitive to all antimicrobials tested. Two pens inoculated with each strain were treated with chlortetracycline and two were not. Chicks were killed on day 7 and caeca were cultured for Salmonella. Experiments were performed independently twice. Chicks exposed to pen mates inoculated with the resistant strain and treated with tetracycline were 90% positive for Salmonella; whereas 60% of chicks given no antimicrobials were positive. Chicks exposed to the sensitive strain were 95% positive with tetracycline treatment and 90% positive without treatment. Conclusions: A multidrug-resistant Salm. Typhimurium strain had significantly increased transmission when chicks were treated with tetracycline. Transmission of a sensitive strain was not inhibited by antimicrobial selective pressure at recommended therapeutic dose. Significance and Impact of the Study: This study demonstrates that antimicrobial usage may influence the transmission of antimicrobial-resistant pathogens in poultry.
引用
收藏
页码:1301 / 1308
页数:8
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