Exploring the expression of the melanin-concentrating hormone messenger RNA in the rat lateral hypothalamus after goldthioglucose injection

被引：9

作者：

Grillon, S ^{[1
]}

Herve, C ^{[1
]}

Griffond, B ^{[1
]}

Fellmann, D ^{[1
]}

机构：

[1] FAC MED,LAB HISTOL EMBRYOL CYTOGENET,INST ETUD & TRANSFERT GENES,CNRS URA 561,F-25030 BESANCON,FRANCE

来源：

NEUROPEPTIDES | 1997年 / 31卷 / 02期

关键词：

D O I：

10.1016/S0143-4179(97)90081-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Melanin-concentrating hormone (MCH) is expressed in a large neuronal population of the rat lateral hypothalamus. This area is known to be implicated in the regulation of thirst and hunger and to contain glucose-sensitive cells. In the present study, we investigated the effects of goldthioglucose (GTG), a toxic form of glucose, on the expression of the MCH gene in the rat lateral hypothalamus by immunocytochemistry, in situ hybridization and competitive RT-PCR. We observed that the MCH immunoreactivity and the level of MCH mRNA were not changed after intraperitoneal GTG injection (0.35 mg/g body weight). These results together with previous data suggest that the glucose-sensitive cells of the lateral hypothalamus are different from the MCH neurons and remain to be identified.

引用

页码：131 / 136

页数：6

共 31 条

[1]

ANAND BK, 1951, YALE J BIOL MED, V24, P123

[2]

[Anonymous], [No title captured]

[3] INSULIN-TREATMENT STIMULATES THE RAT MELANIN-CONCENTRATING HORMONE-PRODUCING NEURONS [J].

BAHJAOUIBOUHADDI, M ;

FELLMANN, D ;

GRIFFOND, B ;

BUGNON, C .

NEUROPEPTIDES, 1994, 27 (04) :251-258

[4] INDUCTION OF FOS-IMMUNOREACTIVITY IN PROLACTIN-LIKE CONTAINING NEURONS OF THE RAT LATERAL HYPOTHALAMUS AFTER INSULIN-TREATMENT [J].

BAHJAOUIBOUHADDI, M ;

FELLMANN, D ;

BUGNON, C .

NEUROSCIENCE LETTERS, 1994, 168 (1-2) :11-15

[5] THE ROLE OF MELANIN-CONCENTRATING HORMONE IN COLOR-CHANGE [J].

BAKER, BI .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1993, 680 :279-289

[6] SALMONID MELANIN-CONCENTRATING HORMONE INHIBITS CORTICOTROPIN RELEASE [J].

BAKER, BI ;

BIRD, DJ ;

BUCKINGHAM, JC .

JOURNAL OF ENDOCRINOLOGY, 1985, 106 (02) :R5-R8

[7] EFFECTS OF CHRONIC ADMINISTRATION OF MELANIN-CONCENTRATING HORMONE ON CORTICOTROPIN, MELANOTROPIN, AND PIGMENTATION IN THE TROUT [J].

BAKER, BI ;

BIRD, DJ ;

BUCKINGHAM, JC .

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1986, 63 (01) :62-69

[8] THE LATERAL HYPOTHALAMIC AREA REVISITED - NEUROANATOMY, BODY-WEIGHT REGULATION, NEUROENDOCRINOLOGY AND METABOLISM [J].

BERNARDIS, LL ;

BELLINGER, LL .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1993, 17 (02) :141-193

[9] THE MELANIN-CONCENTRATING HORMONE SYSTEM OF THE RAT-BRAIN - AN IMMUNIZATION AND HYBRIDIZATION HISTOCHEMICAL CHARACTERIZATION [J].

BITTENCOURT, JC ;

PRESSE, F ;

ARIAS, C ;

PETO, C ;

VAUGHAN, J ;

NAHON, JL ;

VALE, W ;

SAWCHENKO, PE .

JOURNAL OF COMPARATIVE NEUROLOGY, 1992, 319 (02) :218-245

[10] INSITU HYBRIDIZATION HISTOCHEMISTRY FOR THE ANALYSIS OF GENE-EXPRESSION IN THE ENDOCRINE AND CENTRAL-NERVOUS-SYSTEM TISSUES - A 3-YEAR EXPERIENCE [J].

BLOCH, B ;

POPOVICI, T ;

LEGUELLEC, D ;

NORMAND, E ;

CHOUHAM, S ;

GUITTENY, AF ;

BOHLEN, P .

JOURNAL OF NEUROSCIENCE RESEARCH, 1986, 16 (01) :183-200

← 1 2 3 4 →