Expression of trefoil factors 1 and 2 in precancerous condition and gastric cancer

被引：23

作者：

Shi, Shu-Qing ^{[1
]}

Cai, Jian-Ting

Yang, Jian-Ming

机构：

[1] Zhejiang Prov Peoples Hosp, Dept Gastroenterol, Hangzhou 310014, Zhejiang Prov, Peoples R China

[2] Zhejiang Univ, Sch Med, Dept Gastroenterol, Affiliated Hosp 2, Hangzhou 310009, Zhejiang Prov, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2006年 / 12卷 / 19期

关键词：

trefoil factor; gastric cancer; immunohistochemistry;

D O I：

10.3748/wjg.v12.i19.3119

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To study the expression of trefoil factor I (TFF1) and TFF2 in precancerous condition and gastric cancer and to explore the relationship between TFFs and tumorigenesis, precancerous condition and gastric cancer. METHODS: The expression of TFF1 and TFF2 was immunohistochemically analyzed in paraffin-em bedded samples from 140 patients including 35 cases of chronic superficial gastritis (CSG), 35 cases of gastric ulcer (GU), 35 cases of chronic atrophic gastritis (CAG) and 35 cases of gastric cancer (GC). RESULTS: TFF1 and TFF2 were located in cytoplasm of gastric mucous cells. In CSG, GU, CAG and GC, the level of TFF1 expression had a decreased tendency (P < 0.05). The expression of TFF2 was higher in GU than in CSG, but the difference was not significant. The expression of TFF2 also had a decreased tendency in GU, CAG, and GC (P < 0.05). CONCLUSION: The reduced expression of TFF1 and TFF2 in precancerous conditions and gastric cancer may be associated with the proliferation and malignant transformation of gastric mucosa. More investigations are needed to explore the mechanism of TFFs and the relationship between TFFs and gastric cancer. (c) 2006 The WIG Press. All rights reserved.

引用

页码：3119 / 3122

页数：4

共 20 条

[1] EXPERIMENTAL ULCERATION LEADS TO SEQUENTIAL EXPRESSION OF SPASMOLYTIC POLYPEPTIDE, INTESTINAL TREFOIL FACTOR, EPIDERMAL GROWTH-FACTOR AND TRANSFORMING GROWTH-FACTOR-ALPHA MESSENGER-RNAS IN RAT STOMACH [J].