Intestinal growth-promoting properties of glucagon-like peptide-2 in mice

被引:279
作者
Tsai, CH
Hill, M
Asa, SL
Brubaker, PL
Drucker, DJ
机构
[1] UNIV TORONTO, TORONTO HOSP, DEPT MED, TORONTO, ON M5G 2C4, CANADA
[2] UNIV TORONTO, TORONTO HOSP, DEPT PATHOL, TORONTO, ON M5G 2C4, CANADA
[3] UNIV TORONTO, TORONTO HOSP, DEPT PHYSIOL, BANTING & BEST DIABET CTR, TORONTO, ON M5G 2C4, CANADA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 1997年 / 273卷 / 01期
关键词
bowel; growth factor; apoptosis; feeding;
D O I
10.1152/ajpendo.1997.273.1.E77
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Glucagon-like peptide-2 (GLP-2) has been shown to promote intestinal epithelial proliferation. We studied crypt cell proliferation, enterocyte cell death, and feeding behavior in GLP-2-treated mice. GLP-2 had no effect on food consumption [7.7 +/- 0.3 vs. 8.0 +/- 0.4 g/day, saline (control) vs. GLP-2-treated mice, P = not significant]; however, GLP-2 increased the crypt cell proliferation rate (46.0 +/- 1 vs. 57 +/- 5%, control vs. GLP-2, P < 0.01) and decreased the enterocyte apoptotic rate (5.9 +/- 0.7 vs. 2.8 +/- 0.2% apoptotic cells, control vs. GLP-2, P < 0.05) in small bowel (SB) epithelium. GLP-2 induced a significant increase in SB weight (1.3- to 1.75-fold increase over control, P < 0.05 to P < 0.001) in mice 1-24 mo of age. Increased SE weight was maintained after daily administration of GLP-2 to mice for 12 wk, and cessation of GLP-2 administration in older mice led to regression of (increased) SB weight and mucosal height. These observations suggest that GLP-2 regulates both cell proliferation and apoptosis and promotes intestinal growth after both short- and long-term administration in vivo.
引用
收藏
页码:E77 / E84
页数:8
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