Identification of tyrosine hydroxylase as an autoantigen in autoimmune polyendocrine syndrome type I

被引：58

作者：

Hedstrand, H ^{[1
]}

Ekwall, O

Haavik, J

Landgren, E

Betterle, C

Perheentupa, J

Gustafsson, J

Husebye, E

Rorsman, F

Kämpe, O

机构：

[1] Univ Hosp, Dept Med Sci, SE-75185 Uppsala, Sweden

[2] Univ Hosp, Dept Womens & Childrens Hlth, SE-75185 Uppsala, Sweden

[3] Univ Bergen, Dept Biochem & Mol Biol, Bergen, Norway

[4] Univ Padua, Inst Semeiot Med Clin Immunol & Allergy, Padua, Italy

[5] Univ Helsinki, Hosp Children & Adolescents, Helsinki, Finland

[6] Haukeland Univ Hosp, Div Endocrinol, Inst Med, N-5021 Bergen, Norway

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 267卷 / 01期

关键词：

alopecia areata; catecholamine biosynthesis; autoantibodies; tyrosine; 3-monooxygenase;

D O I：

10.1006/bbrc.1999.1945

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Patients with the autosomal recessively inherited autoimmune polyendocrine syndrome type I (APS I) have autoantibodies directed against several endocrine and nonendocrine organs. In this study a new autoantigen related to this syndrome, tyrosine hydroxylase, was identified in sera from patients with alopecia areata through immunoscreening of a scalp cDNA library. Immunoreactivity against in vitro expressed tyrosine hydroxylase was found in 41 (44%) of the 94 APS I patients studied and this reactivity correlated with the presence of alopecia areata (P = 0.02). These findings further stress the importance of enzymes involved in neurotransmitter biosynthesis as important immune targets in APS I. (C) 2000 Academic Press.

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页码：456 / 461

页数：6

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