Effect of implementation of folic acid fortification of food on homocysteine concentrations in subjects with coronary artery disease

被引：8

作者：

Anderson, JL ^{[1
]}

Horne, BD

Carlquist, JF

Bair, TL

Habashi, J

Hart, NI

Jones, SK

Muhlestein, JB

机构：

[1] Latter Day St Hosp, Div Cardiol, Dept Cardiovasc, Salt Lake City, UT 84143 USA

[2] Univ Utah, Sch Med, Salt Lake City, UT USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2002年 / 90卷 / 05期

关键词：

D O I：

10.1016/S0002-9149(02)02531-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Because folic acid may reduce homocysteine (HCY) plasma levels, a new risk factor for coronary artery disease, we tested whether a Food and Drug Administration (FDA) mandate for folic acid fortification of foods would affect plasma HCY among 2,755 subjects studied angiographically over 4 years and at high risk of incident coronary events. Plasma HCY decreased by approximate to2 mumol/L, and the percentage of patients with "high-risk" HCY decreased by 1/3 in temporal association with implementation of the FDA rule.

引用

页码：536 / +

页数：5

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