Nanosuspensions of poorly soluble drugs -: reproducibility of small scale production

被引：124

作者：

Grau, MJ ^{[1
]}

Kayser, O ^{[1
]}

Müller, RH ^{[1
]}

机构：

[1] Free Univ Berlin, Dept Pharmaceut Biopharmceut & Biotechnol, D-12196 Berlin, Germany

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2000年 / 196卷 / 02期

关键词：

drugs; nanoparticles; polydispersity index;

D O I：

10.1016/S0378-5173(99)00411-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The major problem of many newly developed pharmaceutical drugs is their poor solubility in water and simultaneously in organic media. To solve these problems formulation as nanosuspensions is an attractive alternative. During the drug development process screening for an optimal formulation by homogenisation is essential. Time and cost effective production in an initial phase of R&D can be conducted on lab scale by using the Micron Lab 40 in its discontinuous version. In this report reproducibility of small scale production parameters (particle size, size distribution, content of microparticles) was exemplary studied for the drug RMKP22. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：155 / 159

页数：5