Memory disturbances in "Ecstasy" users are correlated with an altered brain serotonin neurotransmission

被引:140
作者
Reneman, L
Booij, J
Schmand, B
van den Brink, W
Gunning, B
机构
[1] Univ Amsterdam, Acad Med Ctr, Dept Nucl Med, Grad Sch Neurosci, NL-1105 AZ Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Dept Neurol, NL-1105 AZ Amsterdam, Netherlands
[3] Univ Amsterdam, Acad Med Ctr, Amsterdam Inst Addict Res, NL-1105 BC Amsterdam, Netherlands
[4] Univ Amsterdam, Acad Med Ctr, Dept Psychiat, NL-1105 BC Amsterdam, Netherlands
[5] Univ Amsterdam, Acad Med Ctr, Dept Child Adolescent Psychiat, NL-1105 AZ Amsterdam, Netherlands
关键词
MDMA; ecstasy; SPECT; 5-HT2; receptor; memory;
D O I
10.1007/s002130050057
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Rationale: Methylenedioxymethamphetamine MDMA) is known to damage brain pre-synaptic serotonin (5-HT) neurons. Since loss of 5-HT neurons has been implicated in memory loss, it is important to establish whether MDMA use may produce changes in postsynaptic 5-HT receptors and memory function in humans. Objectives: To investigate whether MDMA use leads to compensative alterations in post-synaptic 5-HT2A receptors and whether there is a relation with memory disturbances. Methods: Brain cortical 5-HT2A receptor densities were studied with [I-123]-5-I-R91150 SPECT in five abstinent MDMA users and nine healthy controls, Memory performance was assessed using RAVLT. Results. [I-123]-5-I-R91150 binding ratios were significantly higher in the occipital cortex of MDMA users than in controls. indicating up-regulation. Mean cortical 5-HT2A receptor binding correlated positively with RAVLT-recall in MDMA users. Conclusion: Our preliminary results may indicate altered 5-HT neuronal function with correlated memory impairment in abstinent MDMA users.
引用
收藏
页码:322 / 324
页数:3
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