Targeted therapy for non-small-cell lung cancer: past, present and future

被引：49

作者：

Forde, Patrick M. ^{[1
]}

Ettinger, David S. ^{[2
]}

机构：

[1] Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Lung Canc Res Program, Baltimore, MD 21287 USA

[2] Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Baltimore, MD 21287 USA

来源：

EXPERT REVIEW OF ANTICANCER THERAPY | 2013年 / 13卷 / 06期

关键词：

ALK; crizotinib; EGFR; epigenetic; erlotinib; immune checkpoint; non-small-cell lung cancer; PD1; targeted therapy; VEGF; PHASE-III TRIAL; GROWTH-FACTOR RECEPTOR; TYROSINE KINASE INHIBITOR; CISPLATIN PLUS GEMCITABINE; PLACEBO-CONTROLLED TRIAL; GENE COPY NUMBER; DOUBLE-BLIND; 1ST-LINE TREATMENT; OPEN-LABEL; STANDARD CHEMOTHERAPY;

D O I：

10.1586/ERA.13.47

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Therapy for advanced non-small-cell lung cancer has developed significantly with new awareness of histologic subtype as an important factor in guiding treatment and the development of targeted agents for molecular subgroups harboring critical mutations that spur on cancer growth. In this comprehensive review, we look back at developments in targeted therapy for advanced non-small-cell lung cancer, reviewing in detail efforts, both successful and in some cases less so, to target EGFR, VEGF and ALK. This review provides an overview of where the field stands at present and the areas we feel are most likely to provide challenges and potential successes in the next 5 years including immune checkpoint inhibition, epigenetic therapy and driver mutation targeting.

引用

页码：745 / 758

页数：14

共 98 条

[1]

Primary and Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-small Cell Lung Cancer: An Update [J].

Ayoola, Ayodele ;

Barochia, Amit ;

Belani, Kiran ;

Belani, Chandra P. .

CANCER INVESTIGATION, 2012, 30 (05) :433-446

[2]

MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib [J].

Bean, James ;

Brennan, Cameron ;

Shih, Jin-Yuan ;

Riely, Gregory ;

Viale, Agnes ;

Wang, Lu ;

Chitale, Dhananjay ;

Motoi, Noriko ;

Szoke, Janos ;

Broderick, Stephen ;

Balak, Marissa ;

Chang, Wen-Cheng ;

Yu, Chong-Jen ;

Gazdar, Adi ;

Pass, Harvey ;

Rusch, Valerie ;

Gerald, William ;

Huang, Shiu-Feng ;

Yang, Pan-Chyr ;

Miller, Vincent ;

Ladany, Marc ;

Yang, Chih-Hsin ;

Pao, William .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (52) :20932-20937

[3]

MET gene copy number in non-small cell lung cancer: Molecular analysis in a targeted tyrosine kinase inhibitor naive cohort [J].

Beau-Faller, Michele ;

Ruppert, Anne-Marie ;

Voegeli, Anne-Claire ;

Neuville, Agnes ;

Meyer, Nicolas ;

Guerin, Eric ;

Legrain, Michele ;

Mennecier, Bertrand ;

Wihlm, Jean-Marie ;

Massard, Gilbert ;

Quoix, Elisabeth ;

Oudet, Pierre ;

Gaub, Marie P. .

JOURNAL OF THORACIC ONCOLOGY, 2008, 3 (04) :331-339

[4]

ROS1 Rearrangements Define a Unique Molecular Class of Lung Cancers [J].

Bergethon, Kristin ;

Shaw, Alice T. ;

Ou, Sai-Hong Ignatius ;

Katayama, Ryohei ;

Lovly, Christine M. ;

McDonald, Nerina T. ;

Massion, Pierre P. ;

Siwak-Tapp, Christina ;

Gonzalez, Adriana ;

Fang, Rong ;

Mark, Eugene J. ;

Batten, Julie M. ;

Chen, Haiquan ;

Wilner, Keith D. ;

Kwak, Eunice L. ;

Clark, Jeffrey W. ;

Carbone, David P. ;

Ji, Hongbin ;

Engelman, Jeffrey A. ;

Mino-Kenudson, Mari ;

Pao, William ;

Iafrate, A. John .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (08) :863-870

[5]

Comparison of survival and quality of life in advanced non-small-cell lung cancer patients treated with two dose levels of paclitaxel combined with cisplatin versus etoposide with cisplatin: Results of an eastern cooperative oncology group trial [J].

Bonomi, P ;

Kim, KM ;

Fairclough, D ;

Cella, D ;

Kugler, J ;

Rowinsky, E ;

Jiroutek, M ;

Johnson, D .

JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (03) :623-631

[6]

Safety and Activity of Anti-PD-L1 Antibody in Patients with Advanced Cancer [J].

Brahmer, Julie R. ;

Tykodi, Scott S. ;

Chow, Laura Q. M. ;

Hwu, Wen-Jen ;

Topalian, Suzanne L. ;

Hwu, Patrick ;

Drake, Charles G. ;

Camacho, Luis H. ;

Kauh, John ;

Odunsi, Kunle ;

Pitot, Henry C. ;

Hamid, Omid ;

Bhatia, Shailender ;

Martins, Renato ;

Eaton, Keith ;

Chen, Shuming ;

Salay, Theresa M. ;

Alaparthy, Suresh ;

Grosso, Joseph F. ;

Korman, Alan J. ;

Parker, Susan M. ;

Agrawal, Shruti ;

Goldberg, Stacie M. ;

Pardoll, Drew M. ;

Gupta, Ashok ;

Wigginton, Jon M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (26) :2455-2465

[7]

DNA methylation markers and early recurrence in stage I lung cancer [J].

Brock, Malcolm V. ;

Hooker, Craig M. ;

Ota-Machida, Emi ;

Han, Yu ;

Guo, Mingzhou ;

Ames, Stephen ;

Gloeckner, Sabine ;

Piantadosi, Steven ;

Gabrielson, Edward ;

Pridham, Genevieve ;

Pelosky, Kristen ;

Belinsky, Steven A. ;

Yang, Stephen C. ;

Baylin, Stephen B. ;

Herman, James G. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (11) :1118-1128

[8]

Prospective Molecular Marker Analyses of EGFR and KRAS From a Randomized, Placebo-Controlled Study of Erlotinib Maintenance Therapy in Advanced Non-Small-Cell Lung Cancer [J].

Brugger, Wolfram ;

Triller, Nadja ;

Blasinska-Morawiec, Maria ;

Curescu, Stefan ;

Sakalauskas, Raimundas ;

Manikhas, Georgy Moiseevich ;

Mazieres, Julien ;

Whittom, Renaud ;

Ward, Carol ;

Mayne, Karen ;

Trunzer, Kerstin ;

Cappuzzo, Federico .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (31) :4113-4120

[9]

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer [J].

Cameron, EE ;

Bachman, KE ;

Myöhänen, S ;

Herman, JG ;

Baylin, SB .

NATURE GENETICS, 1999, 21 (01) :103-107

[10]

Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study [J].

Camidge, D. Ross ;

Bang, Yung-Jue ;

Kwak, Eunice L. ;

Iafrate, A. John ;

Varella-Garcia, Marileila ;

Fox, Stephen B. ;

Riely, Gregory J. ;

Solomon, Benjamin ;

Ou, Sai-Hong I. ;

Kim, Dong-Wan ;

Salgia, Ravi ;

Fidias, Panagiotis ;

Engelman, Jeffrey A. ;

Gandhi, Leena ;

Jaenne, Pasi A. ;

Costa, Daniel B. ;

Shapiro, Geoffrey I. ;

LoRusso, Patricia ;

Ruffner, Katherine ;

Stephenson, Patricia ;

Tang, Yiyun ;

Wilner, Keith ;

Clark, Jeffrey W. ;

Shaw, Alice T. .

LANCET ONCOLOGY, 2012, 13 (10) :1011-1019

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