CSF biomarkers: Proteomics investigations and clinical applications in neurodegenerative disorders

被引：5

作者：

Gabelle, A. ^{[1
,2
]}

Roche, S. ^{[1
,3
]}

Lehmann, S. ^{[1
,3
]}

机构：

[1] Inst Genet Humaine, CNRS, UPR Stem Cells & Neurodegenerat Dis 1142, Montpellier, France

[2] CHU Gui de Chauliac, Serv Neurol, Unite Neurocomportementale, F-34295 Montpellier 5, France

[3] CHU St Eloi, Biochim Lab, Montpellier, France

来源：

REVUE NEUROLOGIQUE | 2009年 / 165卷 / 03期

关键词：

CSF biomarkers; Proteomics; Dementia; Prions; CREUTZFELDT-JAKOB-DISEASE; MILD COGNITIVE IMPAIRMENT; NEURON-SPECIFIC ENOLASE; MYELIN BASIC-PROTEIN; CEREBROSPINAL-FLUID PROTEINS; INCIPIENT ALZHEIMERS-DISEASE; PHOSPHORYLATED TAU-PROTEIN; FIBRILLARY ACIDIC PROTEIN; MULTIPLE-SCLEROSIS; MASS-SPECTROMETRY;

D O I：

10.1016/j.neurol.2008.05.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Given the current developments of therapeutic strategies in the field of neurodegenerative disorders, exact diagnosis, especially at an early stage, is becoming increasingly crucial for optimal patient care. importantly, the new diagnosis criteria of dementia include functional imagery as well as CSF biomarkers. Proteomics investigations of these CSF biomarkers have produced quite promising results. The interest of CSF analysis resides in the anatomical and pathophysiological characteristics of this fluid. in this article, we will review current proteomics investigations of CSF which have led to the discovery and validation of biomarkers, mainly in the field of neuro degenerative disorders in Alzheimer's disease. (C) 2008 Elsevier Masson SAS.

引用

页码：213 / 222

页数：10

共 67 条

[1] CSF biomarkers for mild cognitive impairment and early Alzheimer's disease [J].