Tipping the balance toward longevity

被引：11

作者：

Antebi, A ^{[1
]}

机构：

[1] Max Planck Inst Mol Genet, D-14195 Berlin, Germany

来源：

DEVELOPMENTAL CELL | 2004年 / 6卷 / 03期

关键词：

D O I：

10.1016/S1534-5807(04)00068-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Genetic experiments in C. elegans suggested that SIR2, an NAD-dependent protein deacetylase, acts through FOXO/DAF-16 transcription factor to prolong life. Recent studies show that mammalian SIR2 deacetylates FOXO, and may maximize survival by tempering cell death and increasing stress resistance.

引用

页码：315 / 316

页数：2

共 10 条

[1] BRUNET A, 2004, IN PRESS SCIENC 0219
[2] Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
Cheng, HL
Mostoslavsky, R
Saito, S
Manis, JP
Gu, YS
Patel, P
Bronson, R
Appella, E
Alt, FW
Chua, KF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (19) : 10794 - 10799
[3] Genetics and the specificity of the aging process
Hekimi, S
Guarente, L
[J]. SCIENCE, 2003, 299 (5611) : 1351 - 1354
[4] Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, KT
Bitterman, KJ
Cohen, HY
Lamming, DW
Lavu, S
Wood, JG
Zipkin, RE
Chung, P
Kisielewski, A
Zhang, LL
Scherer, B
Sinclair, DA
[J]. NATURE, 2003, 425 (6954) : 191 - 196
[5] Negative control of p53 by Sir2α promotes cell survival under stress
Luo, JY
Nikolaev, AY
Imai, S
Chen, DL
Su, F
Shiloh, A
Guarente, L
Gu, W
[J]. CELL, 2001, 107 (02) : 137 - 148
[6] Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway
Miyauchi, H
Minamino, T
Tateno, K
Kunieda, T
Toko, H
Komuro, I
[J]. EMBO JOURNAL, 2004, 23 (01) : 212 - 220
[7] Mammalian SIRT1 represses forkhead transcription factors
Motta, MC
Divecha, N
Lemieux, M
Kamel, C
Chen, D
Gu, W
Bultsma, Y
McBurney, M
Guarente, L
[J]. CELL, 2004, 116 (04) : 551 - 563
[8] The endocrine regulation of aging by insulin-like signals
Tatar, M
Bartke, A
Antebi, A
[J]. SCIENCE, 2003, 299 (5611) : 1346 - 1351
[9] Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
Tissenbaum, HA
Guarente, L
[J]. NATURE, 2001, 410 (6825) : 227 - 230
[10] p53 mutant mice that display early ageing-associated phenotypes
Tyner, SD
Venkatachalam, S
Choi, J
Jones, S
Ghebranious, N
Igelmann, H
Lu, XB
Soron, G
Cooper, B
Brayton, C
Park, SH
Thompson, T
Karsenty, G
Bradley, A
Donehower, LA
[J]. NATURE, 2002, 415 (6867) : 45 - 53

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