The role of microRNA in human leukemia: a review

被引：69

作者：

Yendamuri, S. ^{[2
]}

Calin, G. A. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Unit 36, Houston, TX 77030 USA

[2] Roswell Pk Canc Inst, Dept Thorac Surg, Buffalo, NY 14263 USA

来源：

LEUKEMIA | 2009年 / 23卷 / 07期

关键词：

microRNA; non-coding RNA; microarray; CHRONIC LYMPHOCYTIC-LEUKEMIA; ACUTE MYELOID-LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; B-CELL LYMPHOMAS; DOWN-REGULATION; EXPRESSION PROFILES; MIRNA EXPRESSION; MESSENGER-RNAS; STEM-CELLS; DIFFERENTIATION;

D O I：

10.1038/leu.2008.382

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

MicroRNAs (miRNAs or miRs) are 18-22-nucleotide non-coding RNAs that have emerged as a new paradigm of epigenetic regulation in both normal development and cellular function, and in the pathogenesis of human disease including cancer. This review summarizes the current literature of mechanism of gene regulation by miRNA and their role in hematopoiesis and leukemogenesis. An understanding of these processes suggests further avenues for research to understand gene regulation and miRNA-based therapeutic approaches. Leukemia (2009) 23, 1257-1263; doi: 10.1038/leu.2008.382; published online 15 January 2009

引用

页码：1257 / 1263

页数：7

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