Classical and alternative activation of mononuclear phagocytes: Picking the best of both worlds for tumor promotion

被引：279

作者：

Van Ginderachter, Jo A. ^{[1
]}

Movahedi, Kiavash ^{[1
]}

Ghassabeh, Gholamreza Hassanzadeh ^{[1
]}

Meerschaut, Sofie ^{[1
]}

Beschin, Alain ^{[1
]}

Raes, Geert ^{[1
]}

De Baetselier, Patrick ^{[1
]}

机构：

[1] Vrije Univ Brussel VIB, Cellular & Mol Immunol Lab, Dept Mol & Cellular Interact, B-1050 Brussels, Belgium

来源：

IMMUNOBIOLOGY | 2006年 / 211卷 / 6-8期

关键词：

alternative activation; classical activation; macrophages; cancer progression; myeloid suppressor cells; tumor-associated macrophages;

D O I：

10.1016/j.imbio.2006.06.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mononuclear phagocytes often function as control switches of the immune system, securing the balance between pro- and anti-inflammatory reactions. For this purpose and depending on the activating stimuli, these cells can develop into different subsets: classically (M1) or alternatively (M2) activated mononuclear phagocytes, the molecular and functional characterization of which is a current topic of investigation. Accumulating evidence suggests that cells of the monocyte/macrophage lineage can be hijacked by tumors for their own benefit. Either as immature cells in the periphery, or as mature macrophages at the tumor site, mononuclear phagocytes are able to influence the behavior of cancer cells, shape the tumor microenvironment and subvert anti-tumor immunity, thereby contributing to tumor growth and progression. This review focuses on the mechanisms behind monocyte/macrophage-mediated tumor promotion and interprets the available data within the M1/M2 conceptual frame. (c) 2006 Elsevier GmbH. All rights reserved.

引用

页码：487 / 501

页数：15

共 136 条

[1] Colony-stimulating factor-1 blockade by antisense oligonucleotides and small interfering RNAs suppresses growth of human mammary tumor xenografts in mice [J].