Biologic markers of mortality in acute lung injury

被引：16

作者：

Gaggar, Amit

Olman, Mitchell A.

机构：

[1] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA

[2] Univ Alabama Birmingham, Div Pulm & Crit Care Med, Birmingham, AL 35294 USA

来源：

CLINICA CHIMICA ACTA | 2006年 / 372卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

acute lung injury; biomarkers;

D O I：

10.1016/j.cca.2006.04.019

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Acute lung injury (ALI) is a clinical syndrome in which patients develop severe and progressive pulmonary gas exchange defects and pulmonary mechanical dysfunction. The high morbidity and mortality (40%) associated with ALI provide a compelling need to identify clinical and/or biochemical parameters that robustly risk stratify patients for both accurate prognostication and clinical trial purposes. In this review, we will examine and critically evaluate studies pertaining to biochemical markers of mortality in ALI. These markers may not only serve as prognostic measures of disease, but in some cases, add to our overall understanding of the pathophysiology of ALI. (c) 2006 Elsevier B.V. All rights reserved.

引用

收藏

页码：24 / 32

页数：9

相关论文

共 58 条

[1] Coagulation abnormalities in acute lung injury and sepsis [J].

Abraham, E .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2000, 22 (04) :401-404

[2]

*AC RESP DISTR SYN, 2000, NEW ENGL J MED, V342, P1301, DOI DOI 10.1056/NEJM200005043421801

[3] Evolution of leukotriene B4, peptide leukotrienes, and interleukin-8 plasma concentrations in patients at risk of acute respiratory distress syndrome and with acute respiratory distress syndrome:: Mortality prognostic study [J].

Amat, M ;

Barcons, M ;

Mancebo, J ;

Mateo, J ;

Oliver, A ;

Mayoral, JF ;

Fontcuberta, J ;

Vila, L .

CRITICAL CARE MEDICINE, 2000, 28 (01) :57-62

[4]

Chabot F, 1998, EUR RESPIR J, V11, P745

[5] Prognostic value of surfactant proteins A and D in patients with acute lung injury [J].

Cheng, IW ;

Ware, LB ;

Greene, KE ;

Nuckton, TJ ;

Eisner, MD ;

Matthay, MA .

CRITICAL CARE MEDICINE, 2003, 31 (01) :20-27

[6] Early detection of type III procollagen peptide in acute lung injury - Pathogenetic and prognostic significance [J].

Chesnutt, AN ;

Matthay, MA ;

Tibayan, FA ;

Clark, JG .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1997, 156 (03) :840-845

[7] TYPE-III PROCOLLAGEN PEPTIDE IN THE ADULT-RESPIRATORY-DISTRESS-SYNDROME - ASSOCIATION OF INCREASED PEPTIDE LEVELS IN BRONCHOALVEOLAR LAVAGE FLUID WITH INCREASED RISK FOR DEATH [J].

CLARK, JG ;

MILBERG, JA ;

STEINBERG, KP ;

HUDSON, LD .

ANNALS OF INTERNAL MEDICINE, 1995, 122 (01) :17-23

[8] IDENTIFICATION OF PATIENTS WITH ACUTE LUNG INJURY - PREDICTORS OF MORTALITY [J].

DOYLE, RL ;

SZAFLARSKI, N ;

MODIN, GW ;

WIENERKRONISH, JP ;

MATTHAY, MA .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1995, 152 (06) :1818-1824

[9] Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury [J].

Eisner, MD ;

Parsons, P ;

Matthay, MA ;

Ware, L ;

Greene, K .

THORAX, 2003, 58 (11) :983-988

[10] Time course of procoagulant activity and D dimer in bronchoalveolar fluid of patients at risk for or with acute respiratory distress syndrome [J].

FuchsBuder, T ;

deMoerloose, P ;

Ricou, B ;

Reber, G ;

Vifian, C ;

Nicod, L ;

Romand, JA ;

Suter, PM .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1996, 153 (01) :163-167

← 1 2 3 4 5 6 →