The wilms tumour gene WT1 in leukaemia

被引:25
作者
PritchardJones, K
KingUnderwood, L
机构
[1] Section of Paediatrics, Institute of Cancer Research, Belmont, Sutton, Surrey, SM2-5NG
关键词
WT1; leukaemia; haematopoiesis; Wilms tumour gene;
D O I
10.3109/10428199709059677
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The WT1 gene is essential for kidney development and is mutated in some Wilms tumours. It is also expressed at a high level in many acute leukaemias and in some haematopoietic progenitor cells, and mutations have been found in leukaemias. The function of WT1, which is a zinc finger protein and has domains characteristic of transcription factors, is not well under stood. The level of expression is highest in leukaemias with immature phenotypes. Expression of WT1 is downregulated during differentiation of leukaemic cell lines and high levels of WT1 expression can cause cell cycle arrest and/or apoptosis. This may reflect a role in the control of normal haematopoiesis, which can be abrogated by mutations in the gene and form part of the pathway towards leukaemogenesis.
引用
收藏
页码:207 / &
页数:15
相关论文
共 103 条
[1]   Mutation analysis of the WT1 gene in sporadic childhood leukaemia [J].
Algar, E ;
Blackburn, D ;
Kromykh, T ;
Taylor, G ;
Smith, P .
LEUKEMIA, 1997, 11 (01) :110-113
[2]  
Algar EM, 1996, ONCOGENE, V12, P1005
[3]   THE EXPRESSION OF THE WILMS-TUMOR GENE, WT1, IN THE DEVELOPING MAMMALIAN EMBRYO [J].
ARMSTRONG, JF ;
PRITCHARDJONES, K ;
BICKMORE, WA ;
HASTIE, ND ;
BARD, JBL .
MECHANISMS OF DEVELOPMENT, 1993, 40 (1-2) :85-97
[4]  
Baird Paul N., 1992, Human Molecular Genetics, V1, P301, DOI 10.1093/hmg/1.5.301
[5]  
BENSI L, 1995, HAEMATOLOGICA, V80, P98
[6]   MODULATION OF DNA-BINDING SPECIFICITY BY ALTERNATIVE SPLICING OF THE WILMS-TUMOR WT1 GENE TRANSCRIPT [J].
BICKMORE, WA ;
OGHENE, K ;
LITTLE, MH ;
SEAWRIGHT, A ;
VANHEYNINGEN, V ;
HASTIE, ND .
SCIENCE, 1992, 257 (5067) :235-237
[7]  
BRENNER B, 1992, ONCOGENE, V7, P1431
[8]  
BRIEGER J, 1994, LEUKEMIA, V8, P2138
[9]   LOW-FREQUENCY OF MUTATIONS IN THE WT1 CODING REGION IN WILMS-TUMOR [J].
BROWN, KW ;
WILMORE, HP ;
WATSON, JE ;
MOTT, MG ;
BERRY, PJ ;
MAITLAND, NJ .
GENES CHROMOSOMES & CANCER, 1993, 8 (02) :74-79
[10]   A non-AUG translational initiation event generates novel WT1 isoforms [J].
Bruening, W ;
Pelletier, J .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (15) :8646-8654