Design and Synthesis of 1-Glycosyl-4-{N-[(2′-morpholinethoxy)-phenyl]aminomethyl}-1H-1,2,3-triazoles as Calcium Activators

被引：4

作者：

Li Yuxin ^{[1
]}

Di Fengjuan ^{[1
]}

Wang Duoyi ^{[1
]}

Chen Wei ^{[1
]}

Wan Yingying ^{[1
]}

Li Zhengming ^{[1
]}

机构：

[1] Nankai Univ, Inst Elementoorgan Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2015年 / 31卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Calcium channel; Click chemistry; Glial cell; Glycosyl; Triazole; BIOLOGICAL-ACTIVITY; CLICK CHEMISTRY;

D O I：

10.1007/s40242-015-5134-y

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A series of novel 1-glycosyl-4-{N-[(2'-morpholinethoxy)phenyllaminomethyl}-1H-1,2,3-triazoles was designed and synthesized through a simple and efficient multistep synthetic method in good yields. The 1,2,3-triazole moiety acted as a single disubstituted ring and a linker between carbohydrates(D-glucose, D-galactose, maltose and lactose) and morpholine. The compounds were characterized by H-1 NMR, C-13 NMR and mass spectra(MS). Two different deprotection methods were discussed. The effects of compounds 5a, 5c and 6e on the intracellular calcium ion concentration([Ca2+](i)) in the central neurons of S. exigua were well investigated by calcium imaging technique. The results demonstrated that compound 6e could elevate the calcium concentration in the glial cells, not in the neurons.

引用

页码：952 / 957

页数：6

共 23 条

[1]

A method of computing the effectiveness of an insecticide [J].