Antifungal activity of plant extracts against dermatophytes

The aqueous extracts (15 mu g ml(-1) medium) of 22 plants used in folkloric medicine in Palestine were investigated for their antifungal activity and minimum inhibitory concentrations (MICs) against nine isolates of Microsporum cants, Trichophyton mentagrophytes and Trichophyton violaceum. The extract of the different plant species reduced colony growth of the three dermatophytes by 36 to 100% compared with the control treatment. Antimycotic activity of the extract against the three dermatophytes varied significantly (P<0.05) between test plants. Extracts of Capparis spinosa and Juglans regia completely prevented growth of M. canis and T. violaceum. The most active extracts (90-100% inhibition) were those of Anagallis arvensis, C. spinosa, F. regia, Pistacia lentiscus and Ruta chalapensis against M. canis; Inula viscosa, J. regia and P. lentiscus against I. mentagrophytes; and Asphodelus luteus, A. arvensis, C.spinosa, Clematis cirrhosa, I viscosa, J. regia, P. lentiscus, Plztmbago europea, Ruscus aculeatus, Retema raetam and Salvia fruticosa against T violaceum. The MICs of these most active plants ranged from 0.6 to 40 mu g ml(-1). The three dermatophytes differed significantly with regard to their susceptibility to plant extracts. Trichophyton violaceum was the most susceptible being completely inhibited by 50% of the extracts followed by M. canis and I; mentagrophytes which were completely inhibited by only 23 and 14% of the extracts, respectively.