Engineering Fluorescent Poly(dopamine) Capsules

被引：131

作者：

Chen, Xi ^{[1
]}

Yan, Yan ^{[1
]}

Muellner, Markus ^{[1
]}

van Koeverden, Martin P. ^{[1
]}

Noi, Ka Fung ^{[1
]}

Zhu, Wei ^{[1
]}

Caruso, Frank ^{[1
]}

机构：

[1] Univ Melbourne, Dept Chem & Biomol Engn, Parkville, Vic 3010, Australia

来源：

LANGMUIR | 2014年 / 30卷 / 10期

基金：

澳大利亚研究理事会;

关键词：

MULTIFUNCTIONAL COATINGS; POLYMER CAPSULES; EUMELANIN; DOPAMINE; FUNCTIONALIZATION; MOLECULES;

D O I：

10.1021/la4049133

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The recent development of poly(dopamine) (PDA) capsules provides new opportunities for their application in biology and medicine. To advance the biomedical application of PDA capsules, strategies that enable the preparation of fluorescently labeled PDA (F-PDA) capsules are required, as this will allow evaluation of their cellular interactions using a range of fluorescence-based techniques. Herein, we report a facile approach for the fabrication of F-PDA capsules via the polymerization of dopamine (DA) on sacrificial templates in the presence of hydrogen peroxide (H2O2). F-PDA capsules with well-defined sizes are prepared by templating different organic and inorganic particles. The resulting F-PDA capsules show negligible c-ytotoxicity in He La cells after incubation for 48 h. We also demonstrate visualization of the F-PDA capsules following internalization by HeLa cells using conventional fluorescence microscopy, en route toward detailed investigations on their biological interactions.

引用

收藏

页码：2921 / 2925

页数：5

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