Curcumin Sensitizes Lung Cancer Cells to Cisplatin-Induced Apoptosis Through Superoxide Anion-Mediated Bcl-2 Degradation

被引：73

作者：

Chanvorachote, Pithi ^{[1
]}

Pongrakhananon, Varisa ^{[2
]}

Wannachaiyasit, Sumalee ^{[3
]}

Luanpitpong, Sudjit ^{[2
]}

Rojanasakul, Yon ^{[4
]}

Nimmannit, Ubonthip ^{[2
]}

机构：

[1] Chulalongkorn Univ, Dept Physiol, Fac Pharmaceut Sci, Bangkok 10330, Thailand

[2] Chulalongkorn Univ, Pharmaceut Technol Int Program, Fac Pharmaceut Sci, Bangkok 10330, Thailand

[3] Silpakorn Univ, Fac Pharm, Dept Biopharm, Nakhon Pathom, Thailand

[4] W Virginia Univ, Dept Pharmaceut Sci, Morgantown, WV 26506 USA

来源：

CANCER INVESTIGATION | 2009年 / 27卷 / 06期

关键词：

Curcumin; Cisplatin; Apoptosis; Lung cancer; Bcl-2; degradation; OVARIAN-CANCER; CARCINOMA-CELLS; KAPPA-B; SIGNALING PATHWAY; BLADDER-CANCER; EXPRESSION; ACTIVATION; RESISTANCE; INHIBITION; PROTEIN;

D O I：

10.1080/07357900802653472

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The purpose of this study was to investigate the sensitizing effect of curcumin on cisplatin-induced apoptosis in non-small cell lung cancer (NSCLC) H460 cells. Curcumin was shown to induce superoxide anion generation, down-regulate anti-apoptotic Bcl-2 protein, and subsequently sensitize cells to cisplatin-induced apoptosis. Co-treatment of the cells with curcumin and cisplatin resulted in increased apoptosis and reversal of Bcl-2-mediated cisplatin resistance. The mechanism by which curcumin down-regulates Bcl-2 and sensitizes cells to cisplatin-induced apoptosis involves proteasomal degradation of Bcl-2. These findings indicate a novel pathway for curcumin regulation of Bcl-2, which could benefit the development of a cisplatin sensitizing agent.

引用

页码：624 / 635

页数：12

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