Local proliferation of microglia cells in response to neocortical injury in vitro

被引：19

作者：

Eliason, DA

Cohen, SA

Baratta, J

Yu, J

Robertson, RT ^{[1
]}

机构：

[1] Univ Calif Irvine, Coll Med, Dept Anat & Neurobiol, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Coll Med, Dept Phys Med & Rehabil, Irvine, CA 92697 USA

来源：

DEVELOPMENTAL BRAIN RESEARCH | 2002年 / 137卷 / 01期

关键词：

cerebral cortex;

D O I：

10.1016/S0165-3806(02)00413-3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Studies examined whether increased numbers of microglia following neural damage result from induced mitotic activity of resident microglia in situ. Organotypic slice cultures of neocortex were maintained for 1 week prior to placement of lesions. Increased numbers of OX-6 or tomato lectin labeled microglial cells were detected 1-8 days following lesions. Administration of BrdU to the cultures demonstrated lectin and BrdU double labeled microglial cells, conclusively demonstrating that a portion of the microglial cells were generated by local mitotic activity in situ. (C) 2002 Elsevier Science B.V. All rights reserved.

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收藏

页码：75 / 79

页数：5

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