Capillary electrophoresis for pharmacokinetic studies

被引：15

作者：

Leveque, D

GallionRenault, C

Monteil, H

Jehl, F

机构：

[1] Laboratory of Pharmacokinetics, Institute of Bacteriology, 67000 Strasbourg

来源：

JOURNAL OF CHROMATOGRAPHY B | 1997年 / 697卷 / 1-2期

关键词：

reviews; capillary electrophoresis; pharmacokinetics;

D O I：

10.1016/S0378-4347(97)00335-6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Different analytical techniques involving capillary electrophoresis for the determination of drugs and metabolites in biological fluids are described. Pharmacokinetic studies carried out using capillary electrophoresis are presented, as well as the in vitro metabolism investigations. The advantages and the limitations of capillary electrophoresis for pharmacokinetic studies are discussed. (C) 1997 Elsevier Science B.V.

引用

收藏

页码：67 / 75

页数：9

相关论文

共 87 条

[1] QUANTITATIVE ASPECTS OF THE APPLICATION OF CAPILLARY ELECTROPHORESIS TO THE ANALYSIS OF PHARMACEUTICALS AND DRUG-RELATED IMPURITIES [J].

ALTRIA, KD .

JOURNAL OF CHROMATOGRAPHY, 1993, 646 (02) :245-257

[2] DETERMINATION OF CIMETIDINE IN URINE BY CAPILLARY ZONE ELECTROPHORESIS [J].

ARROWOOD, S ;

HOYT, AM .

MICROCHEMICAL JOURNAL, 1993, 47 (1-2) :90-95

[3] MONITORING OF BENZYLPENICILLIN DECOMPOSITION IN GASTRIC CONTENTS BY CAPILLARY ZONE ELECTROPHORESIS [J].

ARROWOOD, S ;

HOYT, AM ;

SEPANIAK, MJ .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1992, 583 (01) :105-110

[4] CHIRAL DIFFERENTIATION OF THE OPTICAL ISOMERS OF RACEMETHORPHAN AND RACEMORPHAN IN URINE BY CAPILLARY ZONE ELECTROPHORESIS [J].

AUMATELL, A ;

WELLS, RJ .

JOURNAL OF CHROMATOGRAPHIC SCIENCE, 1993, 31 (12) :502-508

[5] FOSFOMYCIN DETERMINATION IN SERUM BY CAPILLARY ZONE ELECTROPHORESIS WITH INDIRECT ULTRAVIOLET DETECTION [J].

BAILLET, A ;

PIANETTI, GA ;

TAVERNA, M ;

MAHUZIER, G ;

BAYLOCQFERRIER, D .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1993, 616 (02) :311-316

[6] Interspecies differences in coumarin metabolism in liver microsomes examined by capillary electrophoresis [J].

Bogan, DP ;

Deasy, B ;

OKennedy, R ;

Smyth, MR .

XENOBIOTICA, 1996, 26 (04) :437-445

[7] DETERMINATION OF FREE AND TOTAL 7-HYDROXYCOUMARIN IN URINE AND SERUM BY CAPILLARY ELECTROPHORESIS [J].

BOGAN, DP ;

DEASY, B ;

OKENNEDY, R ;

SMYTH, MR ;

FUHR, U .

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 1995, 663 (02) :371-378

[8] Cyclodextrins and enantiomeric separations of drugs by liquid chromatography and capillary electrophoresis: Basic principles and new developments [J].

Bressolle, F ;

Audran, M ;

Pham, TN ;

Vallon, JJ .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1996, 687 (02) :303-336

[9] SERUM ANTIPYRINE CONCENTRATIONS DETERMINED BY MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY [J].

BRUNNER, LJ ;

DIPIRO, JT ;

FELDMAN, S .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1993, 622 (01) :98-102

[10] METABOLIC CAGE ISOLATION REDUCES ANTIPYRINE CLEARANCE IN RATS [J].

BRUNNER, LJ ;

DIPIRO, JT ;

FELDMAN, S .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1994, 46 (07) :581-584

← 1 2 3 4 5 6 7 8 9 →