Contributions of myc to tumorigenesis

被引：150

作者：

Lutz, W

Leon, J

Eilers, M

机构：

[1] Univ Marburg, Inst Mol Biol & Tumorforsch, IMT, D-35033 Marburg, Germany

[2] Univ Cantabria, Fac Med, Dept Biol Mol, Santander 39011, Spain

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2002年 / 1602卷 / 01期

关键词：

myc; tumoriogenesis; mechanism; contribution;

D O I：

10.1016/S0304-419X(02)00036-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite intensive research, the mechanisms by which deregulation of myc gene expression contributes to tumorigenesis are still not fully resolved and many aspects are still enigmatic. Several recent reviews, including one published in this series a few months ago, have summarized recent progress in our understanding of the biochemistry of Myc proteins [Eisenmann, Genes Dev. (2001) in press; Amati et al., Biochim. Biophys. Acta 1471 (2001) 135-145]. Also, the evidence documenting a central role of Myc proteins in human tumorigenesis has been extensively reviewed [Henriksson and Uscher, Cancer Res. 68 (1996) 109-182]. In this article, we will argue that current progress allows us to present testable hypotheses on how Myc affects specific properties of transformed cells. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：61 / 71

页数：11

共 88 条

[1] THE C-MYC PROTEIN INDUCES CELL-CYCLE PROGRESSION AND APOPTOSIS THROUGH DIMERIZATION WITH MAX [J].