Preparative resolution of a key intermediate for the synthesis of optically active m-phenylene PGI2 derivatives

被引：12

作者：

Wakita, H

Yoshiwara, H

Tajima, A

Kitano, Y

Nagase, H

机构：

[1] Toray Ind Inc, Basic Res Labs, Kanagawa 2488555, Japan

[2] Toray Res Ctr Ltd, Shiga 5208567, Japan

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 21期

关键词：

D O I：

10.1016/S0957-4166(99)00442-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A key intermediate for the synthesis of optically active m-phenylene PGI(2) derivatives was efficiently resolved on a preparative scale by diastereomeric salt formation method using (+)-cis-N-benzyl-2-(hydroxymethyl)cyclohexylamine ((+)-cis-amine) as a resolving agent. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：4099 / 4105

页数：7

共 8 条

[1]

[Anonymous], 1974, INT TABLES XRAY CRYS, VIV

[2]

NAGASE H, 1990, TETRAHEDRON LETT, V31, P4493

[3] Synthetic study of a new class of stable PGI(2) analogue, m-phenylene PGI(2) - Synthesis of beraprost sodium [J].