Hereditary thrombophilias are not associated with a decreased live birth rate in women with recurrent miscarriage

Objective: To assesses the live birth rate without treatment in women with hereditary thrombophilia who have recurrent miscarriage and women without thrombophilia who have recurrent miscarriage. Design: Prospective observational study. Setting: Tertiary referral unit in university hospital. Patient(s): One hundred twenty women with thrombophilia and 65 women without thrombophilia. Main Outcome Measure(s): Number of live births or repeated miscarriages. Results: Of the 185 patients. 44 with thrombophilia and 26 without thrombophilia have conceived. Nineteen of the 44 pregnancies (43.2%) in thrombophilia patients have terminated in live births, compared with 8 of 26 pregnancies (30.8%) in patients without thrombophilia. This difference is not statistically significant. Conclusions: Hereditary thrombophilia did not seem to affect the live birth rate in women with recurrent miscarriage. (C) 2002 by American Society for Reproductive Medicine.