Relationship between olfactory dysfunction and cognitive impairment in elderly patients with type 2 diabetes mellitus

被引：55

作者：

Sanke, Haruna ^{[1
]}

Mita, Tomoya ^{[1
,4
]}

Yoshii, Hidenori ^{[2
]}

Yokota, Ayako ^{[2
]}

Yamashiro, Keiko ^{[2
]}

Ingaki, Noriko ^{[2
]}

Onuma, Tomio ^{[2
]}

Someya, Yuki ^{[1
]}

Komiya, Koji ^{[1
]}

Tamura, Yoshifumi ^{[1
,5
]}

Shimizu, Tomoaki ^{[1
]}

Ohmura, Chie ^{[1
]}

Kanazawa, Akio ^{[1
,3
]}

Fujitani, Yoshio ^{[1
]}

Watada, Hirotaka ^{[1
,3
,4
,5
]}

机构：

[1] Juntendo Univ, Grad Sch Med, Dept Endocrinol & Metab, Bunkyo Ku, Tokyo 1138421, Japan

[2] Juntendo Tokyo Koto Geriatr Med Ctr, Dept Med Diabetol & Endocrinol, Koto Ku, Tokyo 1360075, Japan

[3] Juntendo Univ, Grad Sch Med, Ctr Therapeut Innovat Diabet, Bunkyo Ku, Tokyo 1138421, Japan

[4] Juntendo Univ, Grad Sch Med, Ctr Mol Diabetol, Bunkyo Ku, Tokyo 1138421, Japan

[5] Juntendo Univ, Grad Sch Med, Sportol Ctr, Bunkyo Ku, Tokyo 1138421, Japan

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2014年 / 106卷 / 03期

关键词：

Olfactory function; Cognitive impairment; Type 2 diabetes mellitus; Elderly patients; MINI-MENTAL-STATE; ALZHEIMERS-DISEASE; ODOR IDENTIFICATION; OLDER-ADULTS; FOLLOW-UP; DEMENTIA; POPULATION; DEFICITS; DECLINE; MEMORY;

D O I：

10.1016/j.diabres.2014.09.039

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Aims: Recent clinical studies identified the relation between olfactory dysfunction and cognitive impairment in the elderly without type 2 diabetes mellitus. The aim of the present study was to define the relation between olfactory function and cognition in elderly patients with type 2 diabetes mellitus. Methods: The study participants comprised 250 elderly (age, 68-77, median 72) Japanese outpatient with type 2 diabetes mellitus free of clinically-evident cognitive impairment. Olfactory and cognitive functions were evaluated by the Open Essence (OE) test and Minimental State Examination (MMSE), respectively. Results: Based on the MMSE score, 62.0%, 24.4%, and 13.6% of the participants were considered to have no impairment, possible cognitive impairment and probable dementia, respectively. The OE test score of the probable dementia group was significantly lower than other groups. Furthermore, age and serum uric acid were significantly higher in the probable dementia group than other groups. Simple correlation analysis showed positive correlation between the MMSE score and diastolic blood pressure, education, OE test score, total cholesterol, LDL cholesterol, folic acid, and negative correlation with age, HbA(1c), aspartate aminotransferase, serum adiponectin and urinary albumin excretion. Multivariate regression analysis showed that OE test score correlated significantly and independently with MMSE score (standardized coefficients beta = 0.542, R-2 = 0.478, P < 0.01), in addition to education level, HbA1c and serum adiponectin. Conclusions: The results suggested the association of olfactory dysfunction with cognitive impairment in elderly patients with type 2 diabetes mellitus. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：465 / 473

页数：9

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