Staphylococcus aureus nasal carriage is associated with glucocorticoid receptor gene polymorphisms

被引：103

作者：

van den Akker, Erica L. T.

Nouwen, Jan L.

Melles, Damian C.

van Rossum, Elisabeth F. C.

Koper, Jan W.

Uitterlinden, Andre G.

Hofman, Albert

Verbrugh, Henri A.

Pols, Huibert A.

Lamberts, Steven W. J.

van Belkum, Alex

机构：

[1] Erasmus Univ, Med Ctr, Dept Pediat, NL-3000 CB Rotterdam, Netherlands

[2] Erasmus Univ, Med Ctr, Dept Internal Med, NL-3000 CB Rotterdam, Netherlands

[3] Erasmus Univ, Med Ctr, Dept Med Microbiol & Infect Dis, NL-3000 CB Rotterdam, Netherlands

[4] Erasmus Univ, Med Ctr, Dept Epidemiol & Biostat, NL-3000 CB Rotterdam, Netherlands

[5] Erasmus Univ, Med Ctr, Dept Clin Chem, NL-3000 CB Rotterdam, Netherlands

来源：

JOURNAL OF INFECTIOUS DISEASES | 2006年 / 194卷 / 06期

关键词：

D O I：

10.1086/506367

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The aim of this study was to determine whether polymorphisms of the glucocorticoid receptor gene, influencing glucocorticoid sensitivity, are associated with persistent nasal carriage of Staphylococcus aureus. Two nasal swab cultures were obtained from each of 2929 participants. Subjects were classified as persistent carriers (n = 563) if both cultures were positive. GG homozygotes of the exon 9 beta polymorphism were associated with a 68% reduced risk of persistent S. aureus nasal carriage, whereas carriers of the codon 23 lysine allele displayed an 80% increased risk. Thus, genotype-dependent variation in the sensitivity to glucocorticoids is associated with tolerance toward staphylococcal nasal colonization.

引用

页码：814 / 818

页数：5

共 16 条

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