The human and mouse complement of SH2 domain proteins -: Establishing the boundaries of phosphotyrosine signaling

被引：182

作者：

Liu, Bernard A.

Jablonowski, Karl

Raina, Monica

Arcé, Michael

Pawson, Tony ^{[1
]}

Nash, Piers D.

机构：

[1] Univ Chicago, Ben May Inst, Chicago, IL 60637 USA

[2] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

来源：

MOLECULAR CELL | 2006年 / 22卷 / 06期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

D O I：

10.1016/j.molcel.2006.06.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SH2 domains are interaction modules uniquely dedicated to the recognition of phosphotyrosine sites and are embedded in proteins that couple protein-tyrosine kinases to intracellular signaling pathways. Here, we report a comprehensive bioinformatics, structural, and functional view of the human and mouse complement of SH2 domain proteins. This information delimits the set of SH2-containing effectors available for PTK signaling and will facilitate the systems-level analysis of pTyr-dependent protein-protein interactions and PTK-mediated signal transduction. The domain-based architecture of SH2-containing proteins is of more general relevance for understanding the large family of protein interaction domains and the modular organization of the majority of human proteins.

引用

页码：851 / 868

页数：18

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