Enantioselective alkynylation of aldehydes catalyzed by [2.2]paracyclophane-based ligands

被引:117
作者
Dahmen, S [1 ]
机构
[1] Cynora GmbH, D-52134 Herzogenrath, Germany
关键词
D O I
10.1021/ol049596b
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[2.2]Paracyclophane-based ketimine ligands were evaluated as catalysts for the enantioselective addition of in situ-prepared alkynylzinc reagents to aldehydes. The initial high activity and enantioselectivity of these ligands could be improved by an additive screening. The final protocol gives chiral propargyl alcohols in up to >98% ee.
引用
收藏
页码:2113 / 2116
页数:4
相关论文
共 12 条