Enantioselective alkynylation of aldehydes catalyzed by [2.2]paracyclophane-based ligands

被引：117

作者：

Dahmen, S ^{[1
]}

机构：

[1] Cynora GmbH, D-52134 Herzogenrath, Germany

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 13期

关键词：

D O I：

10.1021/ol049596b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[2.2]Paracyclophane-based ketimine ligands were evaluated as catalysts for the enantioselective addition of in situ-prepared alkynylzinc reagents to aldehydes. The initial high activity and enantioselectivity of these ligands could be improved by an additive screening. The final protocol gives chiral propargyl alcohols in up to >98% ee.

引用

页码：2113 / 2116

页数：4

共 12 条

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