Does chloroquine really act through oxidative stress?

被引：26

作者：

Monti, D

Basilico, N

Parapini, S

Pasini, E

Olliaro, P

Taramelli, D

机构：

[1] Univ Milan, CNR, ISTM, Dept Organ Chem, I-20133 Milan, Italy

[2] Univ Milan, Inst Microbiol, I-20133 Milan, Italy

[3] WHO, World Bank, UNDP, TDR, CH-1211 Geneva, Switzerland

来源：

FEBS LETTERS | 2002年 / 522卷 / 1-3期

关键词：

carboxyhemoglobin; chloroquine; carbon monoxide; oxygen; malaria; Plasmodium falciparum;

D O I：

10.1016/S0014-5793(02)02881-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To assess whether molecular oxygen and oxidative stress contribute to chloroquine activity, we cultivated strains of Plasmodium falciparum in erythrocytes with carboxyhemoglobin and an atmosphere containing 2% CO, 5% CO2 and 93% N-2. Results indicate that, contrary to common belief, oxygen is not involved in the activity of chloroquine. Reactive radicals formation is suggested. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：3 / 5

页数：3

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