Further studies on the early protective responses of pigs following immunisation with high potency foot and mouth disease vaccine

被引:67
作者
Barnett, PV
Cox, SJ
Aggarwal, N
Gerber, H
McCullough, KC
机构
[1] AFRC, Inst Anim Hlth, Pirbright Lab, Woking GU24 0NF, Surrey, England
[2] Inst Virol & Immunoprophylaxis, CH-3147 Mittelhausern, Switzerland
关键词
foot-and-mouth disease; emergency vaccination; innate immune defences; cytokines;
D O I
10.1016/S0264-410X(02)00242-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The ability of an emergency oil adjuvanted foot-and-mouth disease (FMD) vaccine to elicit early protective immunity in pigs against direct contact homologous challenge was examined. All vaccinates showed reduced viraemia and shedding of FMDV, and certain animals were protected, showing no clinical signs. IL-6, IL-8 and IL-12 were consistently detected in challenged animals that had been vaccinated. Other cytokines-IL-1, IL-2, TNF, TGF and interferons-were not detected. This demonstrates that the vaccine did not induce a systemic inflammatory response, nor a systemic elevation of T lymphocyte activity. Although the IL-6 and IL-8 did not relate to protection, IL-12 production was highest in the protected vaccinated pigs. Thus, the induction of monocytic cell activity, demonstrable by the production of IL-6, IL-8 and IL-12, appears to play a critical role in FMDV emergency vaccine induction of the innate immune defences which relate to early protection against FMD. The possible modes of defence in which such cytokine activity would be involved are discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:3197 / 3208
页数:12
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