Acute interleukin-6 administration impairs athletic performance in healthy, trained male runners

被引：94

作者：

Robson-Ansley, PJ ^{[1
]}

de Milander, L ^{[1
]}

Collins, M ^{[1
]}

Noakes, TD ^{[1
]}

机构：

[1] Univ Cape Town, Dept Human Biol, Res Unit Exercise Sci & Sports Med, ZA-7725 Newlands, South Africa

来源：

CANADIAN JOURNAL OF APPLIED PHYSIOLOGY-REVUE CANADIENNE DE PHYSIOLOGIE APPLIQUEE | 2004年 / 29卷 / 04期

关键词：

prolonged exercise; fatigue; exercise challenge;

D O I：

10.1139/h04-026

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Fatigue is an inevitable consequence of physical activity; yet its biological cause remains uncertain. During exercise, a polypeptide messenger molecule interleukin-6 (IL-6) is actively-produced. Previously, the administration of recombinant IL-6 (rhIL-6) induced a heightened sensation of fatigue in healthy humans at rest. In contrast, anti-IL-6 receptor antibodies reduced the symptoms of chronic fatigue. In the present study, athletic performance during an exercise challenge consisting of a 10-km running time trial was significantly impaired in trained male runners following the administration of a low dose of rhIL-6 compared to the placebo trial.

引用

页码：411 / 418

页数：8

共 20 条

[1] PENETRATION OF INTERLEUKIN-6 ACROSS THE MURINE BLOOD-BRAIN-BARRIER [J].