Clinical and metabolic response to probiotic administration in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial

被引:625
作者
Akkasheh, Ghodarz [1 ]
Kashani-Poor, Zahra [1 ]
Tajabadi-Ebrahimi, Maryam [2 ]
Jafari, Parvaneh [3 ]
Akbari, Hossein [4 ]
Taghizadeh, Mohsen [5 ]
Memarzadeh, Mohammad Reza [6 ]
Asemi, Zatollah [5 ]
Esmaillzadeh, Ahmad [7 ,8 ,9 ]
机构
[1] Kashan Univ Med Sci, Dept Psychiat, Kashan, Iran
[2] Islamic Azad Univ, Tehran Cent Branch, Dept Sci, Fac Sci, Tehran, Iran
[3] Islamic Azad Univ, Arak Branch, Fac Sci, Dept Microbiol, Arak, Iran
[4] Kashan Univ Med Sci, Dept Biostat, Kashan, Iran
[5] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran
[6] Barij Med Plants Res Ctr, Kashan, Iran
[7] Isfahan Univ Med Sci, Food Secur Res Ctr, Esfahan, Iran
[8] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran
[9] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran
关键词
Probiotics; Glucose metabolism; Lipid profiles; Oxidative stress; Depression; PITUITARY-ADRENAL AXIS; C-REACTIVE PROTEIN; BETA-CELL FUNCTION; OXIDATIVE STRESS; INFLAMMATORY CYTOKINES; INSULIN SENSITIVITY; LIPID PROFILE; YOGURT; SUPPLEMENTATION; GLUTATHIONE;
D O I
10.1016/j.nut.2015.09.003
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 [营养与食品卫生学];
摘要
Objective: We are aware of no study examining the effects of probiotic supplementation on symptoms of depression, metabolic profiles, serum high-sensitivity C-reactive protein (hs-CRP), and biomarkers of oxidative stress in patients with major depressive disorder (MDD). The present study was designed to determine the effects of probiotic intake on symptoms of depression and metabolic status in patients with MDD. Methods: This randomized, double-blind, placebo-controlled clinical trial included 40 patients with a diagnosis of MDD based on DSM-IV criteria whose age ranged between 20 and 55 y. Patients were randomly allocated into two groups to receive either probiotic supplements (n = 20) or placebo (n = 20) for 8 wk. Probiotic capsule consisted of three viable and freeze-dried strains: Lactobacillus acidophilus (2 x 10(9) CFU/g), Lactobacillus casei (2 x 10(9) CFU/g), and Bifidobacterium bifidum (2 x 10(9) CFU/g). Fasting blood samples were taken at the beginning and end of the trial to quantify the relevant variables. All participants provided three dietary records (two weekdays and one weekend) and three physical activity records during the intervention. Results: Dietary intake of study participants was not significantly different between the two groups. After 8 wk of intervention, patients who received probiotic supplements had significantly decreased Beck Depression Inventory total scores (-5.7 +/- 6.4 vs. 1.5 +/- 4.8, P = 0.001) compared with the placebo. In addition, significant decreases in serum insulin levels (-2.3 +/- 4.1 vs. 2.6 +/- 9.3 mu IU/mL, P = 0.03), homeostasis model assessment of insulin resistance (-0.6 +/- 1.2 vs. 0.6 +/- 2.1, P = 0.03), and serum hs-CRP concentrations (-1138.7 +/- 2274.9 vs. 188.4 +/- 1455.5 ng/mL, P = 0.03) were observed after the probiotic supplementation compared with the placebo. Additionally, taking probiotics resulted in a significant rise in plasma total glutathione levels (1.8 +/- 83.1 vs. -106.8 +/- 190.7 mu mol/L, P = 0.02) compared with the placebo. We did not find any significant change in fasting plasma glucose, homeostatic model assessment of beta cell function, quantitative insulin sensitivity check index, lipid profiles, and total antioxidant capacity levels. Conclusions: Probiotic administration in patients with MDD for 8 wk had beneficial effects on Beck Depression Inventory, insulin, homeostasis model assessment of insulin resistance, hs-CRP concentrations, and glutathione concentrations, but did not influence fasting plasma glucose, homeostatic model assessment of beta cell function, quantitative insulin sensitivity check index, lipid profiles, and total antioxidant capacity levels. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码:315 / 320
页数:6
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