Antimicrobial activity of a new fluoroquinolone, DU-6859a, against quinolone-resistant clinical isolates of Neisseria gonorrhoeae with genetic alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV

被引：7

作者：

Deguchi, T ^{[1
]}

Yasuda, M ^{[1
]}

Nakano, M ^{[1
]}

Kanematsu, E ^{[1
]}

Ozeki, S ^{[1
]}

Ishihara, S ^{[1
]}

Saito, I ^{[1
]}

Kawada, Y ^{[1
]}

机构：

[1] TOKYO KYOSAI HOSP,DEPT UROL,MEGURO KU,TOKYO 153,JAPAN

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1997年 / 39卷 / 02期

关键词：

D O I：

10.1093/jac/39.2.247

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The in-vitro antimicrobial activity of DU-6859a, a new fluoroquinolone, was tested against 55 clinical isolates of Neisseria gonorrhoeae. The MIC of DU-6859a inhibiting 90% (MIC90) of the isolates with genetic alterations of both the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV was 0.125 mg/L. The MIC90, for isolates with alterations of GyrA alone or without alterations of GyrA or ParC was 0.03 mg/L and 0.004 mg/L, respectively. The potency of DU-6859a against clinical isolates bearing genetic alterations associated with quinolone resistance was significantly greater than that of currently available fluoroquinolones.

引用

页码：247 / 249

页数：3

共 10 条

[1]

[Anonymous], MMWR

[2]

[Anonymous], 1993, M7A3 NCCLS

[3]

Aoki H, 1993, 33 INT C ANT AG CHEM, V302

[4] NEISSERIA-GONORRHOEAE ACQUIRES MUTATIONS IN ANALOGOUS REGIONS OF GYRA AND PARC IN FLUOROQUINOLONE-RESISTANT ISOLATES [J].