A novel modification of the Ritter reaction using trimethylsilyl cyanide

被引：30

作者：

Chen, HG ^{[1
]}

Goel, OP ^{[1
]}

Kesten, S ^{[1
]}

Knobelsdorf, J ^{[1
]}

机构：

[1] WARNER LAMBERT PARKE DAVIS,PARKE DAVIS PHARMACEUT RES DIV,ANN ARBOR,MI 48105

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 45期

关键词：

D O I：

10.1016/0040-4039(96)01890-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new modification of the Ritter reaction using trimethylsilyl cyanide (Me(3)SiCN) is described, which converts their corresponding formamides in high yields using a convenient procedure. The reaction conditions ana mechanism are discussed. In some cases, new formamides are synthesized which cannot be prepared by the classical Ritter reaction. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：8129 / 8132

页数：4

共 6 条

[1]

CHEN HG, 1996, 211 ACS NAT M NEW OR

[2]

Krimen L. I., 1969, ORG REACT, V17, P213, DOI DOI 10.1002/0471264180.0R017.03

[3]

LEONG WW, 1991, COMP ORG SYN, V4, P292

[4] A NEW REACTION OF NITRILES .1. AMIDES FROM ALKENES AND MONONITRILES [J].

RITTER, JJ ;

MINIERI, PP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1948, 70 (12) :4045-4048

[5]

RITTER JJ, 1973, ORG SYNTH, V5, P471

[6] On the Ritter reaction of cyclic hydroxyamines: Synthesis of conformationally-restricted reduced amide dipeptide isosteres [J].

Taylor, GM ;

Baker, SJ ;

Gedney, A ;

Pearson, DJ ;

Sibley, GEM .

TETRAHEDRON LETTERS, 1996, 37 (08) :1297-1300

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