Lichen planus-like eruptions: An emerging side effect of tumor necrosis factor-α antagonists

被引：117

作者：

Asarch, Adam ^{[1
]}

Gottlieb, Alice B. ^{[1
]}

Lee, Jin ^{[1
]}

Masterpol, Katherine S. ^{[1
]}

Scheinman, Pamela L. ^{[1
]}

Stadecker, Miguel J. ^{[2
]}

Massarotti, Elena M. ^{[3
]}

Bush, Michelle L. ^{[1
]}

机构：

[1] Tufts Med Ctr, Dept Dermatol, Boston, MA 02111 USA

[2] Tufts Med Ctr, Dept Pathol, Boston, MA 02111 USA

[3] Brigham & Womens Hosp, Dept Rheumatol, Boston, MA 02115 USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2009年 / 61卷 / 01期

关键词：

TNF-ALPHA; PSORIASIS; THERAPY; INTERFERON-ALPHA-2B; ETANERCEPT; ARTHRITIS; DISEASES;

D O I：

10.1016/j.jaad.2008.09.032

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

As tumor necrosis factor (TNF)-alpha inhibitors gain wider use in clinical practice, it is becoming increasingly evident that these potent immunosuppressants can also induce inflammatory reactions. We present two cases of lichen planus-like eruptions after infliximab and adalimumab therapy for psoriasis, and review the literature on this phenomenon. Eleven cases of lichen planus or lichenoid drug eruptions have been previously reported in patients taking TNF-alpha inhibitors, in addition to several cases of psoriasiform eruptions With a lichenoid histology. Because TNF-alpha has been implicated in the pathogenesis of lichen planus, induction of lichenoid reactions by TNF-alpha inhibition is somewhat unexpected. We consider potential immunologic mechanisms, and suggest that TNF-alpha inhibition may precipitate lichenoid reactions through disruption of a delicate balance between TNF-alpha and interferon-a in susceptible patients. (J Am Acad Dermatol 2009;61:104-11.)

引用

页码：104 / 111

页数：8

共 34 条

[1] LYMPHOCYTE AND MACROPHAGE SUBSETS IN ACTIVE AND INACTIVE LESIONS OF LICHEN-PLANUS [J].