The Wnt/β-catenin pathway:: master regulator of liver zonation?

被引：47

作者：

Burke, Zoe D. ^{[1
]}

Tosh, David ^{[1
]}

机构：

[1] Univ Bath, Dept Biol & Biochem, Ctr Regenerat Med, Bath BA2 7AY, Avon, England

来源：

BIOESSAYS | 2006年 / 28卷 / 11期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1002/bies.20485

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The liver contains two systems for the removal of ammonia-the urea cycle and the enzyme glutamine synthetase. These systems are expressed in a complementary fashion in two distinct populations of hepatocytes, referred to as periportal and perivenous cells. One of the unresolved problems in hepatology has been to elucidate the molecular mechanisms responsible for induction and maintenance of the cellular heterogeneity for ammonia detoxification. There is now a potential molecular explanation for the zonation of the urea cycle and glutamine synthetase based on the Wnt/beta-catenin pathway.

引用

页码：1072 / 1077

页数：6

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