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Randomized trials in melanoma: An update

被引：14
作者：
Eggermont, Alexander M. M. [1 ]
机构：
[1] Dr Daniel Den Hoed Canc Ctr, Erasmus Med Ctr, NL-3075 EA Rotterdam, Netherlands
来源：
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2006年 / 15卷 / 02期
关键词：
D O I：
10.1016/j.soc.2005.12.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
No effective therapy for metastatic melanoma exists. Polychemotherapy or chemoimmunotherapy have not shown survival benefits. Vaccines have shown little activity in stage IV disease. To advance the identification of effective agents, new drugs can and should be offered as first-line treatment. Efforts must be made to,improve understanding of the biology of malignant melanoma. Too many phase III trials have been conducted with a poor understanding of the mechanism of action of the involved drugs.
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页码：439 / +
页数：14
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