A clinical comparison of unrelated cord blood transplantation and unrelated bone marrow transplantation for adult patients with acute leukaemia in complete remission

被引：40

作者：

Ooi, J ^{[1
]}

Iseki, T ^{[1
]}

Takahashi, S ^{[1
]}

Tomonari, A ^{[1
]}

Nagayama, H ^{[1
]}

Ishii, K ^{[1
]}

Ito, K ^{[1
]}

Sato, H ^{[1
]}

Takahashi, T ^{[1
]}

Shindo, M ^{[1
]}

Sekine, R ^{[1
]}

Ohno, N ^{[1
]}

Uchimaru, K ^{[1
]}

Nagamura, F ^{[1
]}

Shirafuji, N ^{[1
]}

Tojo, A ^{[1
]}

Tani, K ^{[1
]}

Asano, S ^{[1
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Dept Haematol & Oncol, Minato Ku, Tokyo 1088639, Japan

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2002年 / 118卷 / 01期

关键词：

acute leukaemia; complete remission; adult; unrelated; cord blood transplantation;

D O I：

10.1046/j.1365-2141.2002.03650.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We performed a clinical comparison of unrelated cord blood transplantation (UCBT) and unrelated bone marrow transplantation in adult acute leukaemia patients in complete remission (CR) who received the same conditioning regimen, graft-versus-host disease (GvHD) prophylaxis and supportive treatment. The incidence of acute GvHD was almost the same between the two groups, but the haematopoietic recovery was delayed and the incidence of chronic GvHD was higher in the UCBT group. The probability of 2 year disease-free survival was similar between the two groups. These results suggest that adult acute leukaemia patients in CR without a suitable donor should be considered as candidates for UCBT.

引用

页码：140 / 143

页数：4

共 10 条

[1] Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen-matched unrelated donor bone marrow: results of a matched-pair analysis
Barker, JN
Davies, SM
DeFor, T
Ramsay, NKC
Weisdorf, DJ
Wagner, JE
[J]. BLOOD, 2001, 97 (10) : 2957 - 2961
[2] Outcome of cord-blood transplantation from related and unrelated donors
Gluckman, E
Rocha, V
BoyerChammard, A
Locatelli, F
Arcese, W
Pasquini, R
Ortega, J
Souillet, G
Ferreira, E
Laporte, JP
Fernandez, M
Chastang, C
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (06) : 373 - 381
[3] Current status of umbilical cord blood hematopoietic stem cell transplantation
Gluckman, E
[J]. EXPERIMENTAL HEMATOLOGY, 2000, 28 (11) : 1197 - 1205
[4] CLINICAL MANIFESTATIONS OF GRAFT VERSUS HOST DISEASE IN HUMAN RECIPIENTS OF MARROW FROM HL-A-MATCHED SIBLING DONORS
GLUCKSBERG, H
STORB, R
FEFER, A
BUCKNER, CD
NEIMAN, PE
CLIFT, RA
LERNER, KG
THOMAS, ED
[J]. TRANSPLANTATION, 1974, 18 (04) : 295 - 304
[5] Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors.
Laughlin, MJ
Barker, J
Bambach, B
Koc, ON
Rizzieri, DA
Wagner, JE
Gerson, SL
Lazarus, HM
Cairo, M
Stevens, CE
Rubinstein, P
Kurtzberg, J
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (24) : 1815 - 1822
[6] Unrelated cord blood transplantation for adult patients with myelodysplastic syndrome-related secondary acute myeloid leukaemia
Ooi, J
Iseki, T
Nagayama, H
Tomonari, A
Ito, K
Shirafuji, N
Tojo, A
Tani, K
Asano, S
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 2001, 114 (04) : 834 - 836
[7] Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia
Rocha, V
Cornish, J
Sievers, EL
Filipovich, A
Locatelli, F
Peters, C
Remberger, M
Michel, G
Arcese, W
Dallorso, S
Tiedemann, K
Busca, A
Chan, KW
Kato, S
Ortega, J
Vowels, M
Zander, A
Souillet, G
Oakill, A
Woolfrey, A
Pay, AL
Green, A
Garnier, F
Ionescu, I
Wernet, P
Sirchia, G
Rubinstein, P
Chevret, S
Gluckman, E
[J]. BLOOD, 2001, 97 (10) : 2962 - 2971
[8] Outcomes among 562 recipients of placental-blood transplants from unrelated donors
Rubinstein, P
Carrier, C
Scaradavou, A
Kurtzberg, J
Adamson, J
Migliaccio, AR
Berkowitz, RL
Cabbad, M
Dobrila, NL
Taylor, PE
Rosenfield, RE
Stevens, CE
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (22) : 1565 - 1577
[9] Standardized, unrelated donor cord blood transplantation in adults with hematologic malignancies
Sanz, GF
Saavedra, S
Planelles, D
Senent, L
Cervera, J
Barragán, E
Jiménez, C
Larrea, L
Martín, G
Martínez, J
Jarque, I
Moscardó, F
Plumé, G
Andreu, R
Regadera, AI
García, I
Mollá, S
Solves, P
de la Rubia, J
Bolufer, P
Benlloch, L
Soler, MA
Marty, ML
Sanz, MA
[J]. BLOOD, 2001, 98 (08) : 2332 - 2338
[10] CHRONIC GRAFT VERSUS HOST SYNDROME IN MAN - A LONG-TERM CLINICOPATHOLOGIC STUDY OF 20 SEATTLE PATIENTS
SHULMAN, HM
SULLIVAN, KM
WEIDEN, PL
MCDONALD, GB
STRIKER, GE
SALE, GE
HACKMAN, R
TSOI, M
STORB, R
THOMAS, ED
[J]. AMERICAN JOURNAL OF MEDICINE, 1980, 69 (02) : 204 - 217

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