A simple stereocontrolled synthesis of salinosporamide A

被引：228

作者：

Reddy, LR ^{[1
]}

Saravanan, P ^{[1
]}

Corey, EJ ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 20期

关键词：

D O I：

10.1021/ja048613p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple and effective stereocontrolled synthesis of salinosporamide A has been developed. This process, the first synthesis of salinosporamide A, is capable of providing the compound in substantial quantities for further biological studies. Salinosporamide A was of special interest as a synthetic target because of its potent in vitro cytotoxic activity against many tumor cell lines (IC50 values of 10 nM or less). Copyright © 2003 American Chemical Society.

引用

页码：6230 / 6231

页数：2

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