Immature myeloid cells and cancer-associated immune suppression

被引：260

作者：

Kusmartsev, S ^{[1
]}

Gabrilovich, DI ^{[1
]}

机构：

[1] Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33612 USA

来源：

CANCER IMMUNOLOGY IMMUNOTHERAPY | 2002年 / 51卷 / 06期

关键词：

cancer; immature myeloid cell; immune suppression; immune tolerance; T-cell response;

D O I：

10.1007/s00262-002-0280-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Impaired balance between mature and immature myeloid cells is one of the hallmarks of cancer. In cancer patients as well as in mouse models there is increasing evidence that progressive tumor growth is associated with an accumulation of immature myeloid cells, monocytes/macrophages, and with a decreased number and function of dendritic cells (DC). This review examines recent findings on the contribution of immature myeloid cells (ImC) to cancer-induced immune suppression.

引用

页码：293 / 298

页数：6

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