The importance of cellular environment to function of the CD44 matrix receptor

被引:87
作者
Kincade, PW
Zheng, Z
Katoh, S
Hanson, L
机构
[1] Oklahoma Medical Research Foundation, Oklahoma City, OK 73104
关键词
D O I
10.1016/S0955-0674(97)80116-0
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Much has been learned recently by experimental manipulation of the structure of CD44 and assessment of the resulting functions, However, even greater structural variation is naturally introduced by CD44-bearing cells. A structural model is now available for the portion of CD44 that recognizes hyaluronan, but it is clear that all domains of the molecule influence CD44 functions.
引用
收藏
页码:635 / 642
页数:8
相关论文
共 76 条
  • [1] CD44 IS THE PRINCIPAL CELL-SURFACE RECEPTOR FOR HYALURONATE
    ARUFFO, A
    STAMENKOVIC, I
    MELNICK, M
    UNDERHILL, CB
    SEED, B
    [J]. CELL, 1990, 61 (07) : 1303 - 1313
  • [2] Glycosylation of CD44 is implicated in CD44-mediated cell adhesion to hyaluronan
    Bartolazzi, A
    Nocks, A
    Aruffo, A
    Spring, F
    Stamenkovic, I
    [J]. JOURNAL OF CELL BIOLOGY, 1996, 132 (06) : 1199 - 1208
  • [3] REGULATION OF CD44 BINDING TO HYALURONAN BY GLYCOSYLATION OF VARIABLY SPLICED EXONS
    BENNETT, KL
    MODRELL, B
    GREENFIELD, B
    BARTOLAZZI, A
    STAMENKOVIC, I
    PEACH, R
    JACKSON, DG
    SPRING, F
    ARUFFO, A
    [J]. JOURNAL OF CELL BIOLOGY, 1995, 131 (06) : 1623 - 1633
  • [4] CD44 ISOFORMS CONTAINING EXON V3 ARE RESPONSIBLE FOR THE PRESENTATION OF HEPARIN-BINDING GROWTH-FACTOR
    BENNETT, KL
    JACKSON, DG
    SIMON, JC
    TANCZOS, E
    PEACH, R
    MODRELL, B
    STAMENKOVIC, I
    PLOWMAN, G
    ARUFFO, A
    [J]. JOURNAL OF CELL BIOLOGY, 1995, 128 (04) : 687 - 698
  • [5] The protein fold of the hyaluronate-binding proteoglycan tandem repeat domain of link protein, aggrecan and CD44 is similar to that of the C-type lectin superfamily
    Brissett, NC
    Perkins, SJ
    [J]. FEBS LETTERS, 1996, 388 (2-3) : 211 - 216
  • [6] Molecular mechanisms regulating the hyaluronan binding activity of the adhesion protein CD44
    Chiu, RK
    Droll, A
    Cooper, DL
    Dougherty, ST
    Dirks, JF
    Dougherty, GJ
    [J]. JOURNAL OF NEURO-ONCOLOGY, 1995, 26 (03) : 231 - 239
  • [7] CD44 and hyaluronan-dependent rolling interactions of lymphocytes on tonsillar stroma
    Clark, RA
    Alon, R
    Springer, TA
    [J]. JOURNAL OF CELL BIOLOGY, 1996, 134 (04) : 1075 - 1087
  • [8] O-linked glycosylation modifies CD44 adhesion to hyaluronate in colon carcinoma cells
    Dasgupta, A
    Takahashi, K
    Cutler, M
    Tanabe, KK
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 227 (01) : 110 - 117
  • [9] CD44 and its ligand hyaluronate mediate rolling under physiologic flow: A novel lymphocyte-endothelial cell primary adhesion pathway
    DeGrendele, HC
    Estess, P
    Picker, LJ
    Siegelman, MH
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (03) : 1119 - 1130
  • [10] DOUGHERTY GJ, 1994, J BIOL CHEM, V269, P9074