Hyperglycaemia suppresses the secretion of ghrelin, a novel growth-hormone-releasing peptide: responses to the intravenous and oral administration of glucose

被引:151
作者
Nakagawa, E
Nagaya, N
Okumura, H
Enomoto, M
Oya, H
Ono, F
Hosoda, H
Kojima, M
Kangawa, K
机构
[1] Natl Cardiovasc Ctr, Dept Internal Med, Suita, Osaka 5658565, Japan
[2] Natl Cardiovasc Ctr Hosp & Res Inst, Dept Biochem, Suita, Osaka 5658565, Japan
关键词
ghrelin; glucose; growth hormone; hyperglycaemia;
D O I
10.1042/cs1030325
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Ghrelin is a novel growth hormone (GH)-releasing peptide, isolated from the stomach, which may also cause a positive energy balance by stimulating food intake and reducing fat utilization. However, whether glucose influences the release of ghrelin remains unknown. Accordingly, we examined circulating levels of ghrelin and GH in response to the intravenous or oral administration of 50 g of glucose in eight healthy humans. After the administration of intravenous glucose (50 g), the plasma ghrelin level decreased significantly from 127 +/- 9 to 98 +/- 9 fmol/ml (P < 0.01), associated with an increase in plasma glucose from 85 +/- 3 to 357 +/- 19 mg/dl (P < 0.01). Ingestion of 50 g of glucose decreased the plasma ghrelin level significantly from 134 +/- 12 to 97 +/- 15 fmol/ml (P < 0.01), associated with an increase in plasma glucose from 93 +/- 3 to 166 +/- 10 mg/dl (P < 0.01). The decrease in the plasma ghrelin level lasted for more than 30 min after recovery of the plasma glucose level. In conclusion, ghrelin secretion may be suppressed, at least in part, by an increased plasma glucose level in healthy humans.
引用
收藏
页码:325 / 328
页数:4
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