Pilot trial of albuterol in spinal muscular atrophy

被引：95

作者：

Kinali, M

Mercuri, E

Main, M

De Biasia, F

Karatza, A

Higgins, R

Banks, LM

Manzur, AY

Muntoni, F

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Paediat, London, England

[2] Univ London Imperial Coll Sci Technol & Med, Dubowitz Neuromuscular Ctr, London, England

[3] Univ London Imperial Coll Sci Technol & Med, Dept Physiotherapy, London, England

[4] Univ London Imperial Coll Sci Technol & Med, Dept Musculoskeletal Surg, London, England

来源：

NEUROLOGY | 2002年 / 59卷 / 04期

关键词：

D O I：

10.1212/WNL.59.4.609

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aim of this pilot study was to evaluate the effect of albuterol in children with spinal muscular atrophy (SMA). Thirteen patients (five with SMA II and eight with SMA III) were given oral albuterol for 6 months. There was a significant increase in myometry,forced vital capacity, and lean body mass between the baseline and the 6-month assessments (p < 0.05). Albuterol may have a beneficial effect in patients with SMA without causing any significant adverse effects. Larger randomized, placebo-controlled trials are needed to confirm this observation.

引用

页码：609 / 610

页数：2

共 8 条

[1] Reference values of maximum isometric muscle force obtained in 270 children aged 4-16 years by hand-held dynamometry [J].