Hepatocellular carcinoma: Radio-frequency ablation of medium and large lesions

被引:836
作者
Livraghi, T
Goldberg, SN
Lazzaroni, S
Meloni, F
Ierace, T
Solbiati, L
Gazelle, GS
机构
[1] Osped Civile, Dept Radiol, I-20059 Vimercate, Italy
[2] Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA USA
[3] Osped San Biagio, Dept Internal Med, Clusone, Italy
[4] Osped Gen, Dept Radiol, Busto Arsizio, Italy
[5] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Radiol, Boston, MA USA
关键词
hepatitis; liver; cirrhosis; CT; interventional procedures; US; liver neoplasms; therapy; radiofrequency (RF) ablation;
D O I
10.1148/radiology.214.3.r00mr02761
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
PURPOSE: To study local therapeutic efficacy, side effects, and complications of radiofrequency (RF) ablation in the treatment of medium and large hepatocellular carcinoma (HCC) lesions in patients with cirrhosis or chronic hepatitis. MATERIALS AND METHODS: One-hundred fourteen patients who were under conscious sedation or general anesthesia had 126 HCCs greater than 3.0 cm in diameter treated with RF by using an internally cooled electrode. Eighty tumors were medium (3.1-5.0 cm), and 46 were large (5.1-9.5 cm). The mean diameter for all tumors was 5.4 cm. At imaging, 75 tumors were considered noninfiltrating, and 51 were considered infiltrating. RESULTS: Complete necrosis was attained in 60 lesions (47.6%), nearly complete (90%-99%) necrosis in 40 lesions (31.7%), and partial (50%-89%) necrosis in the remaining 26 lesions (20.6%). Medium and/or noninfiltrating tumors were treated successfully significantly more often than large and/or infiltrating tumors. Two major complications (death, hemorrhage requiring laparotomy) and five minor complications (self-limited hemorrhage, persistent pain) were observed. The single death was due to a break in sterile technique rather than to the RF procedure itself. CONCLUSION: RF ablation appears to be an effective, safe, and relatively simple procedure for the treatment of medium and large HCCs.
引用
收藏
页码:761 / 768
页数:8
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