Docking study of enantiomeric fonofos oxon bound to the active site of Torpedo californica acetylcholinesterase

被引：9

作者：

Hirashima, A ^{[1
]}

Kuwano, E ^{[1
]}

Eto, M ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch, Div Bioresource & Bioenvironm Sci, Fukuoka 8128581, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2000年 / 8卷 / 03期

关键词：

D O I：

10.1016/S0968-0896(99)00315-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Molecular interaction between enantiomeric fonofos oxon (O-ethyl S-phenyl ethylphosphonothiolate) and acetylcholinesterase (AChE) of Torpedo californica was evaluated by using the Cerius2 program. It was suggested that the difference in the inhibitory activity of the two enantiomers of fonofos oxon on AChE is due to the steric hindrance in binding to the AChE active site. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：653 / 656

页数：4

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