Controling stem cell proliferation - CKIs at work

被引：6

作者：

Bruggeman, Sophia W. M. ^{[1
]}

van Lohuizen, Maarten ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Mol Genet, NL-1066 CX Amsterdam, Netherlands

来源：

CELL CYCLE | 2006年 / 5卷 / 12期

关键词：

CKI; adult stem cells; self-renewal; polycomb group; Bmi1;

D O I：

10.4161/cc.5.12.2806

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The cyclin-dependent kinase inhibitors or CKIs are well recognized as intrinsic regulators of the cell cycle. Here, we discuss recent data implicating their activity in restraining adult stem cell self-renewal, and the role that proteins regulating CKI expression play in this process.

引用

页码：1281 / 1285

页数：5

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