Dysmetabolic syndrome: Multiple risk factors for premature adult disease in an adolescent girl

被引：17

作者：

Falkner, B

Hassink, S

Ross, J

Gidding, S

机构：

[1] Thomas Jefferson Univ, Dept Med, Philadelphia, PA 19107 USA

[2] Thomas Jefferson Univ, Dept Pediat, Philadelphia, PA 19107 USA

[3] Alfred I Dupont Hosp Children, Wilmington, DE 19803 USA

来源：

PEDIATRICS | 2002年 / 110卷 / 01期

关键词：

obesity; hypertension; insulin resistance; diabetes; lipids; children;

D O I：

10.1542/peds.110.1.e14

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The clinical diagnosis of dysmetabolic syndrome in an adult defines a patient with abnormal glucose metabolism (or diabetes), hypertension, hyperlipidemia, and obesity. This disorder accelerates atherosclerosis and significantly raises the risk for cardiovascular events. With the marked rise in the prevalence of obesity in childhood, obesity-linked risk factors are being expressed at young ages. The case of a 12-year-old girl with dysmetabolic syndrome is described and discussed. Emerging clinical data now indicate that the presence of 1 risk factor for cardiovascular disease in an overweight child should prompt screening for additional clinical abnormalities, with the aim of finding treatable disorders.

引用

页数：5

共 24 条

[1]

*AM AC PED, 1992, PEDIATRICS, V89, P525

[2]

[Anonymous], 2001, GUID DOC US IN VITR

[3]

[Anonymous], 1997, ARCH INTERN MED, V157, P2413, DOI [10.1001/archinte.1997.00440420033005, DOI 10.1001/ARCHINTE.1997.00440420033005]

[4] A clinical trial of the effects of dietary patterns on blood pressure [J].

Appel, LJ ;

Moore, TJ ;

Obarzanek, E ;

Vollmer, WM ;

Svetkey, LP ;

Sacks, FM ;

Bray, GA ;

Vogt, TM ;

Cutler, JA ;

Windhauser, MM ;

Lin, PH ;

Karanja, N .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (16) :1117-1124

[5] Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults [J].

Berenson, GS ;

Srinivasan, SR ;

Bao, WH ;

Newman, WP ;

Tracy, RE ;

Wattigney, WA .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (23) :1650-1656

[6] CHANGES IN PONDEROSITY AND BLOOD-PRESSURE IN CHILDHOOD - THE MUSCATINE STUDY [J].

CLARKE, WR ;

WOOLSON, RF ;

LAUER, RM .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1986, 124 (02) :195-206

[7] Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) [J].

Cleeman, JI ;

Grundy, SM ;

Becker, D ;

Clark, LT ;

Cooper, RS ;

Denke, MA ;

Howard, WJ ;

Hunninghake, DB ;

Illingworth, DR ;

Luepker, RV ;

McBride, P ;

McKenney, JM ;

Pasternak, RC ;

Stone, NJ ;

Van Horn, L ;

Brewer, HB ;

Ernst, ND ;

Gordon, D ;

Levy, D ;

Rifkind, B ;

Rossouw, JE ;

Savage, P ;

Haffner, SM ;

Orloff, DG ;

Proschan, MA ;

Schwartz, JS ;

Sempos, CT ;

Shero, ST ;

Murray, EZ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (19) :2486-2497

[8] Validation of the Framingham Coronary Heart Disease prediction scores - Results of a multiple ethnic groups investigation [J].

D'Agostino, RB ;

Grundy, S ;

Sullivan, LM ;

Wilson, P .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (02) :180-187

[9] EFFECT OF GROWTH ON VARIABILITY OF LEFT-VENTRICULAR MASS - ASSESSMENT OF ALLOMETRIC SIGNALS IN ADULTS AND CHILDREN AND THEIR CAPACITY TO PREDICT CARDIOVASCULAR RISK [J].

DESIMONE, G ;

DEVEREUX, RB ;

DANIELS, SR ;

KOREN, MJ ;

MEYER, RA ;

LARAGH, JH .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1995, 25 (05) :1056-1062

[10] 10-YEAR OUTCOMES OF BEHAVIORAL FAMILY-BASED TREATMENT FOR CHILDHOOD OBESITY [J].

EPSTEIN, LH ;

VALOSKI, A ;

WING, RR ;

MCCURLEY, J .

HEALTH PSYCHOLOGY, 1994, 13 (05) :373-383

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