Correlation of p53 and bcl-2 expression with vascular endothelial growth factor (VEGF), microvessel density (MVD) and clinicopathological features in colon cancer

被引：40

作者：

Perrone, G

Vincenzi, B

Santini, D

Verzì, A

Tonini, G

Vetrani, A

Rabitti, C

机构：

[1] Serv Histopathol, Rome, Italy

[2] Med Oncol Unit, Rome, Italy

[3] Univ Naples Federico II, Dept Anat Pathol & Cytopathol, Naples, Italy

来源：

CANCER LETTERS | 2004年 / 208卷 / 02期

关键词：

bcl2; p53; angiogenesis; vascular endothelial growth factor;

D O I：

10.1016/j.canlet.2003.11.032

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study was designed to elucidate the possible relationship between tumour related genes and angiogenesis in colon cancer. The protein expression of p53, bcl-2, Von Willebrand factor and vascular endothelial growth factor (VEGF) were analysed by immunohistochemistry in 57 paraffin-embedded colon cancer. The results showed that microvessel density (MVD) was lower in VEGF negative tumours than in VEGF positive ones (P < 0.0001). MVD and VEGF in p53 negative tumours were significantly lower than in p53 positive tumours (respectively, P = 0.003 and P < 0.0001). Moreover, positive correlations were recorded between VEGF expression and MVD, and bcl-2 expression (respectively, P < 0.0001 and P = 0.009). Our data confirm the central role of VEGF in angiogenesis and suggest direct correlations among p53, bcl-2 and VEGF expression in colon cancer. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：227 / 234

页数：8

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